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Articles by V.K. Gopalakrishnan
Total Records ( 2 ) for V.K. Gopalakrishnan
  V. Sathya and V.K. Gopalakrishnan
  Hepatocellular carcinoma ranks as the eighth most common cancer, sixth among men and eleventh among women and accounts for half a million deaths per year. Natural products, especially plants have been used for the treatment of various diseases for thousands of years which contain no side effects. The main aim and objective of the study is in vitro analysis of compounds such as epicatechin, myricetin, naringenin against Hep3B cell line and VERO cell line. In vitro assay of Hep3B cell line and VERO cell line was done by MTT assay. The assay is based on the reduction of soluble yellow tetrazolium salt to insoluble purple formation crystals by metabolically active cells. In vitro assay revealed that compounds such as epicatechin, myricetin and naringenin have efficacy in Hep3B cancer cell line and VERO normal cell line. By comparing the obtained results of MTT assay with these literature survey reports, it could be concluded that the compound has the potential to protect the cells from damage and the possible mechanism might be the inhibition of oxidative and inflammatory processes.
  C. Uma , C. Muthulakshmi , D. Gomathi and V.K. Gopalakrishnan
  The present study is aimed at the production of bio-ethanol from two fungal strains with the addition of the enzyme invertase using sugarcane bagasse as the substrate. Optimization for production of ethanol from sugarcane bagasse was determined by enzymatic saccharification using fungal strains. Enzymatic hydrolysis of sugarcane bagasse and ethanol fermentation from lignocellulosic hydrolysate were investigated by three different methods namely separate hydrolysis and fermentation process, simultaneous saccharification and fermentation and co-culture methods. The enzyme invertase from two different fungal strains were supplemented and the ethanol yield was calculated. Result of the present study report growth optimization of two fungal strains capable of saccharifying sugarcane bagasse. The hydrolyzed material was then fermented with the help of yeast into ethanol. Result of the study reveals the ethanol production by C. cladosporioides was higher (48%) after 48 h of fermentation under static condition by using submerged fermentation.
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