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Articles by V. Singh
Total Records ( 3 ) for V. Singh
  V. Singh and S.Z. Ali
  Starches from cereals (maize, wheat, rice, sorghum, finger millet, waxy rice), pulses (green gram, chick pea) tuber (potato and root (tapioca) were converted to non-granular form and hydrolysed in a homogenous phase. In vitro hydrolysis by α-amylase at 37 °C for 5 to 30 min was carried out and the same starches were also modified with 0.5 N HCl at 37°C for 0.75 to 3 h. Molecular weight of the starches decreased to 7-35% of the respective initial values at the end of 5 min and down further to 3-15% at the end of 30 min. Acid hydrolysis in comparison was very slow. At the end of 3 h, of the resultant starches was still 18-70% of their initial . Degradative pattern of 20 min enzyme hydrolysed starches was studied by gel permeation chromatography on Sepharose CL-6B column. The carbohydrate content of the Fraction-I (void volume, Fr-I) decreased from 81 to 21% after hydrolysis and that of Fraction-II (Fr-IIA and Fr-IIB) increased. The increase was more (from 4.9 to 43.4%) in Fr-IIB (towards total volume). The in the peak of this fraction had a range of 2 x 103 to 9 x 103 indicating that the enzyme hydrolysis in non-granular state produced very low molecular weight dextrins in comparison to granular hydrolysis. The resistance for enzyme hydrolysis, in descending order was found to be finger millet, potato, chickpea, rice, sorghum, green gram, wheat, tapioca, waxy rice and maize. The λmax of iodine complex of enzyme hydrolysed fractions was low in comparison to their respective native fractions. Maximum drop of >100 nm was noted in Fr-IIA, which had comparatively higher values for their respective native fractions indicating that hydrolysed product had many branch points. The higher λmax for peak of Fr-IIB indicated that carbohydrate content corresponding to this peak represented long linear chain fraction probably coming from external chains of the amylopectin molecule.
  V. Singh and S. Z. Ali
  Starches from wheat, maize, finger millet, tapioca, green gram, chick pea, and potato were acid modified using 0.5N HCl, HNO3, H2SO4, and H3PO4 at 50°C for 1.5 h. Alkali Fluidity Number (AFN) for native starches was very low (0.3-2.5) and increased upon modification. HCl and HNO3 produced the highest AFN followed by H2SO4 and H3PO4 . For each acid, cereal and millet starches showed the highest AFN, followed by root, pulse and tuber starches. The extent of hydrolysis was proportional to number average molecular weight (LJFP_A_308543_O_XML_IMAGES\LJFP_A_308543_O_ILM0001.gif), of the native starch in the case of HCl and HNO3 but not in other acids. Intrinsic viscosity [η] of native starches showed positive correlation to their LJFP_A_308543_O_XML_IMAGES\LJFP_A_308543_O_ILM0001.gif,. However, the [η] of the modified starches, particularly those produced by HCl and HNO3 , showed no proportionality with their LJFP_A_308543_O_XML_IMAGES\LJFP_A_308543_O_ILM0001.gif, indicating diverse structural differences in the hydrolsed products. Special behavior of finger millet starch is clear from [η] values of these four acid modified starches. The iodine binding capacity (IBC) of starches, although decreased (2 to 36%) upon modification, did not follow any particular pattern. About 0.01 to 0.94% starch got solubilized during modification—highest being in case of HCl and lowest for H3PO4 . Their LJFP_A_308543_O_XML_IMAGES\LJFP_A_308543_O_ILM0001.gif and IBC were considerably lower in all cases except potato, which showed same IBC for the solubilized, as well as granular modified starch.
  D Yadav , J Chandra , S Sharma and V. Singh
 

First-line therapies of acute and chronic idiopathic thrombocytopenic purpura (ITP) include intravenous immunoglobulin, IV anti-D and corticosteroids. A short-course high-dose dexamethasone (HDD-SC) therapy has recently been reported to be efficacious in acute ITP. The present study was conducted to assess the efficacy of HDD-SC in children with chronic ITP. Over a period of 10 months, 13 patients with chronic ITP were given HDD-SC (20 mg m–2 IV daily for 4 days, four cycles repeated every 15 days). Of the 12 patients who could be evaluated, complete response was observed in 8 (66.6%) and moderate response in 2 (17%) patients, whereas 2 (17%) patients had no response. HDD-SC appears to be a safe and effective therapy in childhood ITP.

 
 
 
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