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Articles by V. Ravichandiran
Total Records ( 2 ) for V. Ravichandiran
  T.S. Shanmugarajan , M. Arunsundar , I. Somasundaram , E. Krishnakumar , D. Sivaraman and V. Ravichandiran
  The current communication was designed to assess the cardioprotective effect of the methanolic leaf extract of Ficus hispida Linn. (FH) (400 mg kg-1 body weight, administered orally for 10 days) on cyclophosphamide (CP) provoked oxidative injury in rat heart. CP cardiotoxicity, induced by single intraperitoneal injection (200 mg kg-1 b.wt.), was revealed by elevated serum creatine phosphokinase (CPK), lactate dehydrogenase (LDH), aspartate transaminase (AST) and alanine transaminase (ALT). CP induced rats, treated with FH depicted near normalcy in these parameters. In the CP group, increased oxidative stress was evidenced by a significant rise in myocardial malondialdehyde (MDA) level and decline in superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST) and reduced glutathione (GSH) activities in the heart tissue. FH treated rats displayed a significant inhibition of lipid peroxidation (LPO) and augmentation of endogenous antioxidants. These results give credence to the notion that treatment with F. hispida leaf extract ameliorates CP induced cardiotoxicity and might serve as a novel combination therapy with CP to combat oxidative stress-mediated myocardial injury.
  B. Rajkapoor , S. Kavimani , V. Ravichandiran , K. Sekhar , R. Senthil Kumar , M. Rupesh Kumar , M. Pradeepkumar , John Wilking Einstein and E.P. Kumar
  The effect of ethanol extract of stems of Indigofera aspalathoides Vahl (Papilionaceae) (EIA) was evaluated for anti-arthritic activity on complete Freund’s adjuvant-induced (CFA-induced) arthritis in rats. The EIA was administered orally at doses of 250 and 500mg/kg daily for 30 days. The paw volume was measured on days 7, 14, 21 and 30. At the end of day 30, the rats were sacrificed and various biochemical parameters such as serum aspartate transaminase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total cholesterol and triglycerides were estimated. Antioxidant enzymes, such as superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx) and lipid peroxide (LPO) in the liver and kidney of normal, arthritic control and EIA treated rats were studied. Oral administration of EIA effectively inhibits rat paw edema in a dose-dependent manner. EIA significantly (P<0.01) altered the biochemical parameters which were affected in arthritic rats. There was significant alteration in LPO, SOD, catalase, and GPx levels when compared to arthritic control rats. Our findings showed a significant anti-arthritic effect of EIA against CFA-induced arthritis in rats.
 
 
 
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