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The present study was aimed to analyze methionine synthase reductase (MTRR) A66G polymorphism in Uttar Pradesh (UP) population and PCR-RFLP method was used for the mutation analysis. Total 104 samples were analyzed and AA genotype was found in 10 individuals, AG genotype in 67 individuals and GG in 27 individuals. The frequencies of AA, AG and GG genotypes in the present study were also assessed with the expected distribution (i.e. Hardy-Weinberg equilibrium) by using χ2 test. The genotype frequencies of AA, AG and GG were 0.096, 0.644 and 0.259, respectively. Allelic frequencies of A and G were 0.418 and 0.581. It was reflected from the results of the present study that the percentage of heterozygous genotype (AG) is highest in the target population.
