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Articles by V. Prasad
Total Records ( 4 ) for V. Prasad
  V. Prasad , V. Jain and P.R. Mishra
  The present study was aimed to measure absorption and disposition of cyclosporine in endotoxin pretreated rats. Cyclosporine (Sandimmune, 10 mg kg-1) was orally administered with and without a concomitant dose of endotoxin (5 mg kg-1) i.p. to rats. Cyclosporine concentrations in blood samples were determined by HPLC UV detector. The pharmacokinetic parameters were calculated by noncompartmental analysis using WINNONLIN. The pretreatment of endotoxin in rats significantly increased cyclosporine AUC0-t (area under the concentration-time curve from time zero to the last point) by 33% in rats, indicating that the rats pretreating with endotoxin significantly increased cyclosporine oral bioavailability. In vitro absorption study was done to assess the effect of endotoxin on cyclosporine absorption. However, the significant increase in permeation drug into serosal side was noticed in rats, when pretreated with endotoxin, thus the inverted sac study also supported the finding of endotoxin inhibited the function of intestinal P-gp thus making cyclosporine more absorbed into lumen. The increased absorption of cyclosporine in both in vitro and in vivo may be due to inhibitory activity of endotoxin on intestinal P-gp and Cytochrome P4503A. This is significant in cases when cyclosporine was administered as immunosuppressant agent in patients suffering from septimea. A paired Student`s t-test was conducted for statistical comparison in all experiments.
  V. Prasad , V. Jain and A.K. Dorle
  Momordica charantia ghrita contains cow’s ghee and Momordica charantia, as its main constituents and rock salt. In the present study an attempt has been made to evaluate Momordica charantia ghrita for immunomodulatory activity. MG was administered orally at doses of 175 and 350 mg/kg/day to healthy rats. Assessment of immunomodulatory activity was carried out by testing the humoral (antibody titre) and cellular (foot pad swelling) immune responses to the antigenic challenges with sheep RBCs and by neutrophil adhesion test. Orally administered MG showed a significant increase of test parameters viz., neutrophil test, Haemagglutinating Antibody Ttitre (HAT) and Delayed Type Hypersensitivity (DTH) response. In rats immunized with sheep RBC, MG enhanced the humoral antibody response to the antigen and significantly potentiated the cellular immunity by facilitating the foot pad thickness response to sheep RBC in sensitized rats. There was dose dependent increase in immunomodulation, there was significant improvement compared to control group and the differences were statistically significant in 350 mg/kg/day, therefore Momordica charantia ghrita promises strong utility in clinical practice as an effective immunostimulant.
  V. Prasad , V. Jain and A.K. Dorle
  S. K. Varshney , H. Monobe , Y. Shimizu , H. Takezoe and V. Prasad
  The synthesis and mesomorphic properties of novel non-symmetrical discotic dimers have been investigated. Dimers have been prepared by the combination of electron-deficient (n-type) anthraquinone and electron-rich (p-type) triphenylene discotic monomers. The mesophases have been characterised using polarising optical microscopy, differential scanning calorimetry and X-ray diffraction. Most of the dimers have been shown to exhibit a rectangular columnar mesophase and one has a nematic columnar mesophase also. Charge transfer behaviour has been studied by UV-Vis spectroscopy.
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