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Articles by V. Manigandan
Total Records ( 4 ) for V. Manigandan
  P. Thirunavukkarasu , T. Ramanathan , G. Umamaheshwari , V. Manigandan and P. Dinesh
  Ipomoea pes-caprae is a sand dune plant commonly used as folklore medicine for fisherman communities based on the traditional knowledge. Little information is available on the feasibility of applying micropropagation techniques for production of dune and marsh species. The main aim of this study is to increase the callus induction and shoot generation of sand dune plant Ipomoea pes-caprae with easily available low cost natural materials. Coconut water is the rich source of carbohydrate and other nutrients which enhance callus and plant regeneration. In our present study, we tried different type of MS medium (Full and half strength) with coconut water at three different percentage (10, 15, 20%) and different concentration of plant growth regulators for callus induction and shoot regeneration. Well-developed callus inoculated in full and half strength MS medium with different concentration of CW and plant growth regulators. The best results were accomplished with half strength MS medium with 15% coconut water and with 2, 4-D and IAA 0.7 mg L-1 concentration which shows better callus induction and shoot regeneration. Young shoot and root developed plants transferred to green house and then followed to soil.
  V. Manigandan and T. Ramanathan
  Docking is one of the important computational tools for identifying the structural modeling and predicting the activity of potential drug. The β-Amyloid (Aβ) and acetylcholine (AChE) are playing a role in the neurotoxicity associated with Alzheimer’s disease. In the present study, five mangroves derived compounds such as avicenol A, betulinic acid, lupeol, quercetin and triterpenoid were selected for docking with target Aβ and ACHE. Lamarckian genetic algorithm methodology was employed for docking. The important parameters like binding energy, length of a hydrogen bond, amino acid residues, cluster and reference RMSD were determined. Betulinic acid and triterpenoid showed higher binding energy (-5.54 and -46.79 kcal mol-1) on Aβ and AChE esterase receptor than compared to other derivatives.
  V. Manigandan , S. Gurudeeban , K. Satyavani and T. Ramanathan
  Computer aided drug design is playing an important role in identifying the drug targets. The contribution of cyclooxygenase-2 (COX-2) to peripheral inflammation and brain inflammation is well documented. Therefore, the present study aimed to evaluate inhibitory effect of Rhizophora mucronata derived alkaloids such as ajmalicine, vindoline, catharanthine, serpentine and tabersonin on COX 2. Based on Lamarckian genetic algorithm, the alkaloids were docked with target protein using Auto Dock 4.0. The results indicated serpentine and ajmalicine expresses higher binding energy (-9.16 and -8.12 kcal mol-1), length of a hydrogen bond (2.211 and 2.079), amino acid residues (HIS 388) on cyclooxygenase 2 receptor than compared to other derivatives. This study concludes that serpentine and ajmalicine acts as a potent source for anti-neuro-inflammatory agents. Further preclinical studies will be carried out to find out the exact molecular level mechanism and drug development for neuro inflammation disorders.
  P. Thirunavukkarasu , T. Ramanathan , S. Asha , V. Manigandan and D. Kannan
  Rhizophora apiculata, a mangrove specie is used in traditional medicine against several human diseases including tumor. To validate the ethnopharmacological claims against cancer, we examined the effects of Rhizophora apiculata leaf oil on the anti gastric cancer activities of Benzo(a)pyrene (BaP) induced gastric cancer in albino mice. The animals were divided into five groups. Group I were given BaP (40 mg kg-1 b.wt.) with 100 μL sesame oil by oral gavage twice a week for 4 consecutive weeks. Group II were given 100 μL sesame oil (SMO) treated (Vehicle treated control) a week for 4 consecutive weeks. Group III mice (BaP) (40 mg kg-1 b.wt.)+R. apiculata (50 μL) for 14 weeks. Group IV only R. apiculata (50 μL kg-1 b.wt.) dialy for two weeks. Goup V as the control non treated. At end of 14 weeks, all the animal were killed. Tumor incidence was observed to be 100% in mice that received only BaP. However, treatment with R. apiculata oil reduced the tumor incidence as observed in mice of BaP+R. apiculata oil group when compared to that of BaP group. Similarly, the tumor burden and body weight were seen to decrease by 137.21, respectively in mice of BaP+R. apiculata oil group when compared to those of BaP group. Diminished lipid peroxidation in the stomach tumor tissue was associated with enhanced antioxidant levels. In contrast to tumor tissue, enhanced lipid peroxidation with compromised antioxidant defences was found in the liver and erythrocytes of tumor bearing animals. Administration of R. apiculata oil significantly reduced the incidence of stomach tumors, modulated lipid peroxidation and enhanced antioxidant status in the stomach, liver and blood. From the results of our study, we suggest that R. apiculata oil may exert its chemopreventive effects by modulating lipid peroxidation and enhancing the antioxidant status in the stomach, liver and erythrocytes.
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