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Articles by V. Kapoor
Total Records ( 3 ) for V. Kapoor
  R. Singh , V. Kapoor and V. Kumar
  The present study deals with the standardization of different cultural conditions for extracellular α-amylase production by thermophilic Streptomyces sp. MSC702 in submerged fermentation (SmF). The appropriate incubation period (48 h), temperature (50°C) and pH (7.0) were determined. The effects of derived and natural carbon sources, inorganic and organic nitrogen sources were also examined. Maximum α-amylase production i.e., 435.71 and 373.89 U mL-1 were achieved by employing derived (D-inositol) and natural (rice bran) carbon sources, respectively. Among the tested nitrogen sources, ammonium sulphate and peptone were found the best inorganic and organic sources, respectively. The C:N ratio found to be the optimum was 1:1. The highest α-amylase activity (807.64 U mL-1) was obtained by utilizing rice bran and wheat bran in 1:2 ratio as the substrate with supplements of D-inositol (1% w/v), ammonium sulphate (0.5% w/v) and peptone (1% w/v). By using the optimized cultural conditions with further characterization, this α-amylase may be utilized in wide spread applications like detergent, saccharification and pharmaceutical industry.
  R. Mahajan , K. Gupta and V. Kapoor
  Metabolic Syndrome (MS) is a collection of risk factors including insulin resistance, central obesity, hypertension and dyslipidemia and itself is a risk factor for coronary artery disease. In recent times, its prevalence is on a rise in obese children too. Many working criteria for diagnosing MS are doing-the-round; given by World Health Organization, Adult Treatment Panel 3 and American Association of Clinical Endocrinologists. Risk factors involved in the pathogenesis of MS are many-fold; accordingly pharmacotherapy of MS is also multifacet. This review article is an account of pathogenesis, diagnosis and available treatment options in MS with a brief account of future prospect.
  K. Gill , A.K. Singh , S. Kumar , B. Mishra , V. Kapoor , S.N. Das , R.K. Somvanshi and S. Dey
  Ginger has been used in traditional Indian and Chinese medicine and is effective for a wide range of ailments including diarrhea, respiratory disorders, inflammatory diseases, arthritis etc. Recent studies have shown the role of ginger extract in the modulation of biochemical pathways involved in chronic inflammation and have thus provided evidences for its anti-inflammatory property. The aim of the study was to identify and purify a novel protein from ginger rhizomes (Zingiber officinales), of Zingiberaceae family possessing anti-fungal, anti-inflammatory and anti-proliferative properties as elicited using antibiotic diffusion method, surface plasmon resonance, spectrophotometric analysis and flow cytometry, respectively. The purified protein G-24 having molecular mass of 24 kD exhibited a potent anti-fungal activity against the mycelial growth in Fusarium exysporum and Candida albicans. It had shown 60% inhibition of human oral cancer cell line (KB cells) at 10 μM concentration. It inhibited inflammatory enzymes; lipooxygenase (LOX) and cyclooxygenase-2 (COX-2) with KD values of 2.04 μM and 2.74 nM, respectively. This confirmed the anti-inflammatory property of G-24.Thus, concluded that the G-24 protein possessed multiple functions viz. antifungal, anti-inflammation and antiproliferation.
 
 
 
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