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Articles by V. W. V Jaddoe
Total Records ( 2 ) for V. W. V Jaddoe
  A Lebon , J. A. M Labout , H. A Verbrugh , V. W. V Jaddoe , A Hofman , W. J. B van Wamel , A van Belkum and H. A. Moll

Objective  To study the association between Staphylococcus aureus nasal colonization and atopic dermatitis (AD) in infancy.

Design  Population-based prospective cohort study of pregnant women and their children.

Setting  This project was embedded in the Generation R Study.

Participants  A total of 1079 postnatal Dutch infants/children participated in the focus cohort.

Main Exposures  Nasal swabs for S aureus cultivation were taken at ages 1.5, 6, and 14 months.

Main Outcome Measure  Questionnaires that pertain to AD and confounders (birth weight, gestational age, sex, and parental eczema) were completed prenatally and postnatally. The outcome was AD in the first and second years of life.

Results  A first positive culture for S aureus at age 6 months was associated with AD prevalence in the first and second years of life (adjusted odds ratio [aOR], 2.13; 95% confidence interval [CI], 1.17-3.87; and aOR, 2.88; 95% CI, 1.60-5.19, respectively) and also with severity (aOR, 3.27; 95% CI, 1.30-8.03). Moreover, frequent colonization in the first year of life (≥2 times) held a 4.29-fold (95% CI, 1.03- to 17.88-fold) risk of moderate to severe AD in the second year of life.

Conclusion  Colonization with S aureus at age 6 months and frequent colonization in the first year of life are associated with AD and its severity in young children.

  L Ay , V. A. A Van Houten , E. A. P Steegers , A Hofman , J. C. M Witteman , V. W. V Jaddoe and A. C. S. Hokken Koelega

Objectives: The objectives of the study was to examine which parental, fetal, and postnatal characteristics are associated with fat and lean mass at the age of 6 months and examine the effect of growth (catch-down, catch-up) in fetal life and early infancy on fat and lean mass.

Design: This study was embedded in the Generation R Study, a prospective cohort study from early fetal life onward. Body composition was measured by dual-energy X-ray absorptiometry in 252 infants at 6 months. Parental, fetal, and postnatal data were collected by physical and fetal ultrasound examinations and questionnaires.

Results: Children with fetal catch-up in weight (gain in weight sd score >0.67) in the second trimester tended to have a higher fat mass percentage [FM(%)] at 6 months of age, whereas children with fetal catch-down in weight had a lower FM(%) compared with nonchangers. In the third trimester, both catch-up and catch-down in weight were associated with an increase in FM(%) at 6 months. Children with catch-down in the third trimester had a greater risk for postnatal catch-up in weight greater than 0.67 sd score. Birth weight and weight at 6 wk were positively associated with fat mass at 6 months. Postnatal catch-up in weight within 6 wk after birth had the highest association with total and truncal FM(%) at 6 months. Total and truncal FM were higher in girls.

Conclusion: Catch-down in weight in the third trimester was strongly associated with postnatal catch-up within 6 wk after birth, and both were associated with an increase in fat mass at the age of 6 months. Our study shows that fetal as well as postnatal growth patterns are associated with body composition in early childhood.

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