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Articles by V. Mrudula
Total Records ( 3 ) for V. Mrudula
  R. Manoj Kumar , R. Anbazhagan , C.C. Satheesh , V. Balamurugan , V. Mrudula and K. Porteen
  The vertebrate body is an ideal breeding ground for viruses and provides the conditions that promote their growth, survival and transmission. Vertebrates have developed immunity and at the same time the invading viruses have discovered elegant ways to circumvent the host`s immune mechanisms. One of the defense strategies that counteract the immune responses of the infected host exploits viral immunomodulators that directly interfere with the host`s cytokine system. Virus encoded immunomodulators (Virokines), enables viruses to create favorable habitat, which preserves them by protecting against damage from the inflammatory response, as well as by blocking apoptosis, until the virus replicates to high titers and finds another host. Virokines are clinically and therapeutically beneficial to the medical field and also having potential implications in viral epidemiology, treatment or prevention of viral and inflammatory diseases and for the development of safer vaccines. The endogenous secretion of the virus immunomodulators is thus emerging as an important mechanism of viral control, which is potentially inducible by effective vaccines. The in depth knowledge of the interactions between viruses and the virokines may lead to novel therapeutic and preventive strategies for the control of viral inflammatory diseases. There is no doubt that these virokines will serve as useful starting points for the development of new treatment tools in the new millennium.
  R. Manojkumar and V. Mrudula
  Zoonoses are generally defined as animal diseases that are transmissible to humans. They continue to represent an important health hazard in most parts of the world, where they cause considerable expenditure and losses for the health and agricultural sectors. The emergence of these zoonotic diseases are very distinct, hence their prevention and control will require unique strategies, apart from traditional approaches. Such strategies require rebuilding a cadre of trained professionals of several medical and biologic sciences. Since there is no way to predict when or where the next important new zoonotic pathogen will emerge or what its ultimate importance might be, investigation at the first sign of emergence is particularly important. Some of the important viral emerging and reemerging zoonoses are several encephalitis causing viruses, hantaan virus, rift valley fever virus, rabies, influenza, SARS corona virus, nipah virus, hendra virus and hepatitis E virus. The success of detection and control of these emerging zoonoses is largely based on international solidarity and cooperation. In this review article we summarized some of the emerging and reemerging viral zoonotic diseases, their probable cause and importance in the process of causing life threatening pandemics.
  V. Mrudula , Titus, V. , George , C. Balachandran and B. Murali Manohar
  The study on canine nephritis was carried out over a period of one year on sixty dogs (60) presented at the Small Animal Clinics, Madras Veterinary College, with clinical signs suggestive of renal insufficiency and 30 dogs with gross nephritis lesions submitted to the department of Veterinary Pathology. The mean age of affected animals was 7.8 ? 0.34 years. Sixty percent of the animals affected were males and 40 % were females. Aged dogs (mean - 7.8 ? 0.34 years) were more susceptible for nephritis. German shepherd (26.66 %) and Spitz (21.66 %) showed a higher incidence of nephritis. E.coli was the principal organism isolated from urine samples. In this study, out of 56 cases studied histopathologically, majority of the animals showed subacute and chronic type of nephritis. The increased incidence of subacute and chronic type of nephritis suggested that renal diseases were not diagnosed in the early stages because of the less sensitivity of routinely used screening tests like BUN and serum creatinine.
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