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Articles by V. Hazeena Begum
Total Records ( 4 ) for V. Hazeena Begum
  T. Ramesh , R. Mahesh and V. Hazeena Begum
  This study is performed to investigate the harmful effects of cigarette smoke on lung antioxidant defense system and restorative property of Sesbania grandiflora in rat lung. Adult male WKY rats were exposed to cigarette smoke for a period of 90 days and consecutively treated with aqueous suspension of S. grandiflora (1000 mg kg-1 b.w./day, p.o) for a period of 3 weeks. The level of lipid peroxide was evaluated as marker of lung damage. Antioxidant status of the lung was assessed from the levels of reduced glutathione, vitamin C and vitamin E and the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione-S-transferase and glucose-6-phophate dehydrogenase. The levels of copper, zinc, manganese and selenium in lung were also measured. Increased lipid peroxidation was evident from the diminished levels of both enzymatic and non-enzymatic antioxidants. Alterations in the levels of trace elements with elevation of copper and depletion of zinc, manganese and selenium were also observed. S. grandiflora administration ameliorated the antioxidant status and maintained the levels of trace elements. These results suggest that chronic cigarette smoke exposure enhances oxidative stress, thereby disturbing the tissue defense system and S. grandiflora protects the lung from the oxidative damage through its antioxidant potential.
  P. Soundararajan , R. Mahesh , T. Ramesh and V. Hazeena begum
  A. lanata aqueous suspension was tested for its biopotency on membrane bound enzymes and marker enzymes in urolithiasis in male albino rats. Calcium oxalate urolithiasis was induced by 0.75% ethylene glycol in drinking water for 28 days. There was a significant decrease in membrane bound enzymes such as Na+K+ATPase, Ca2+ATPase, Mg2+ATPase and marker enzymes Aspartate Transaminase (AST), Alanine Transaminase (ALT), Alkaline Phosphatase (ALP) and Gamma-Glutamyl Transferase (GGT) in kidney and liver while Lactate Dehydrogenase (LDH) was increased. In serum electrolytes, sodium was reduced and K, Ca and Mg levels were elevated. The AST, ALT, ALP, LDH and GGT were increased in serum and urine of urolithic rats. Therapeutic treatment with A. lanata aqueous suspension (2 g kg-1 b.wt. dose-1 day-1 oral-1) has significantly ameliorated to near normalcy in the curative group. The results showed that A. lanata might represent an alternative form of treatment and/or prevention of urolithiasis.
  T. Ramesh , R. Mahesh and V. Hazeena Begum
  The aim of present study to assesse the harmful effects of chronic cigarette smoking on membrane-bound ATPases and the protective effect of S. grandiflora in rat lung, liver, kidney and heart. Adult male WKY rats were exposed to cigarette smoke for a period of 90 days and consecutively treated with aqueous suspension of S. grandiflora (1000 mg kg-1 b.w/day, p.o) for a period of 3 weeks. The levels of lipid peroxides as marker for evaluating the extent of membrane damage, the activities of Na+-K+-ATPase, Ca2+-ATPase and Mg2+-ATPase and associated cations sodium (Na+), potassium (K+), calcium (Ca2+) and magnesium (Mg2+) were investigated in rat lung, liver, kidney and heart. Membrane damage was evident from the increased levels of lipid peroxides, decreased activities of membrane-bound ATPases and alterations in the levels of inorganic cations were observed in cigarette smoke exposed rats. Administration of aqueous suspension of S. grandiflora (ASSG) inhibited the levels of lipid peroxides, ameliorated the activities of membrane-bound ATPases and maintained the ionic equilibrium in rats exposed to cigarette smoke. The results of our study indicate that ASSG protects the membrane-bound ATPases from cigarette smoking induced membrane damage.
  R. Mahesh and V. Hazeena Begum
  The present study was aimed to evaluate the oxidants, enzymatic and nonenzymatic antioxidants, glycoproteins and membrane adenosine triphosphatases (ATPases). The increased levels of oxidants and decreased levels of enzymatic, nonenzymatic antioxidants, glycoproteins and ATPases were observed in erythrocytes of aged rats. After administration of Terminalia chebula, the levels were reverted to normal in aged rats. These results indicate that the administration of T. chebula acts as a free radical scavenger with potential antioxidant effects in erythrocytes of aged rats.
 
 
 
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