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Articles by Umi Kalsum
Total Records ( 2 ) for Umi Kalsum
  Indra Taufik Sahli , Umi Kalsum and Sumarno Reto Prawiro
  Bacterial Biofilm (BF) is a structural form of a group of microorganisms protected by an extracellular matrix which is called Extracellular Polymeric Substance (EPS). Staphylococcus BF EPS consists of Polysaccharide Intercellular Adhesin (PIA), extracellular-DNA, protein and amyloid fibrils. The purpose of this study was to determine the characterization of S. aureus bacterial BF protein based on molecular weight, hemagglutinin protein and see the response of BF protein polyclonal antibodies to several antigens from S. aureus bacteria. The results of the study of BF protein profiles using SDS-PAGE have a molecular weight of 35, 22.4 and 17 kDa. Protein 22.4 kDa has the highest titer (1/4) in the hemagglutination test using mice erythrocytes, so, it is continued to make polyclonal antibodies. BF protein antibodies of 22.4 kDa S. aureus can respond to several antigens from S. aureus bacteria which have a molecular weight of 120, 63, 48, 30 and 22.4 kDa. BF protein S. aureus compossed polymer protein and as can hemagglutinin protein.
  Nurlaili Susanti , Choirun Nissa , Salwin N. Serina , Retty Ratnawati , Nurdiana , Sutiman B. Sumitro , Djoko W. Soeatmadji , Umi Kalsum , M. Aris Widodo and Simon B. Widjanarko
  Dietary fiber from glucomannan has been studied to decrease blood glucose concentration, but its mechanism in diabetes is still unclear. The aim of our research is to study the effect of glucomannan, derived from konjac flour, in rat models of diabetes including gastrointestinal function, inhibition of DPP-IV enzyme and reducing in insulin resistance. A total of 25 male wistar rats were divided into 5 groups; normal group (Normal), diabetes group (DM), diabetes group administered with 100 mg/kg BW konjac flour (DM+KF1), 200 mg/kg BW konjac flour (DM+KF2) and 400 mg/kg BW konjac flour (DM+KF3). Diabetes was induced by a combination of 60% high fructose diet and twice intraperitoneal injection of streptozotocin (25 and 30 mg/kg BW) at one week interval. Konjac flour was given according to each dose for 4 weeks. At the end of the study, blood and tissue sample were collected for subsequent analysis, while isolated intestine used to measure jejunal serous glucose concentration using everted sac technique. The results indicate that glucomannan reduced fasting blood glucose levels, improved glucose tolerance, increased jejunal serous glucose concentration at in vitro technique and decreased insulin resistance as evidenced by a decreased in HOMA-IR index and increased in PI3K levels. However, glucomannan not decreased DPP-4 levels in any dose. This results indicate that glucomannan derived from Konjac flour had antidiabetic effects through improving in glucose homeostasis and reducing in insulin resistance in rat models of diabetes.
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