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Articles by U.Z. Faruk
Total Records ( 2 ) for U.Z. Faruk
  S.W. Hassan , R.A. Umar , Y.U. Dabai , A.A. Ebbo and U.Z. Faruk
  The aqueous and organic solvent leaves extracts of Pteridium aquilinum were screened for antibacterial activity by hole-in-plate bioassay procedure. The effect of aqueous leaves extract of the plant on hepatorenal functions in rabbits was also studied. Hexane (HX) fraction at 10 to 120 mg mL-1 did not show activity against Escherichia coli and Pseudomonas aeruginosa. However, it was significantly (p<0.05) active against Staphylococcus aureus at 90 and 120 mg mL-1. The chloroform (CHL) extract fraction at concentrations of 50-120 mg mL-1 was significantly (p<0.05) active on all the bacterial species. Petroleum ether (PE) at 10-120 mg mL-1 showed significant (p<0.05) inhibition of S. aureus and E. coli. Aqueous (W) extract exhibited significant inhibitory activity at 50-120 mg mL-1 on S. aureus and P. aeruginosa. Tannins, anthraquinone glycosides, cardiac glycosides, cyanogenic glycosides and volatile oils were detected in the extracts. The lethal dose (LD50) of the aqueous leaves extracts was found to be greater than 3000 mg kg-1 (p.o.) in rabbits. Non significant (p>0.05) and significant (p<0.05) changes in renal and liver indices, respectively were observed. Aqueous leaves extract of Pteridium aquilinum is toxic to the liver of rabbits only at 1500-3000 mg kg-1. These results have provided scientific evidence to justify the indigenous use of the plant against infectious diseases.
  S.W. Hassan , M. Lawal , B.Y. Muhammad , R.A. Umar , L.S. Bilbis , U.Z. Faruk and A.A. Ebbo
  The in vitro antifungal activity and phytochemical properties of column chromatography fractions of Hexane (HX), Petroleum Ether (PE) and Chloroform (CHL) of stem bark of Ficus sycomorus were studied. The bioactive agent in the most potent fraction with antifungal properties was isolated and identified by preparative Thin Layer Chromatography (TLC) and phytochemical analysis. The hexane fractions (HX2 and HX3) were significantly active (p<0.05) at 0.31 to 5.63 mg mL-1 on Microsporum gypseum, Aspergillus niger, Aspergillus flavus and Candida albicans. The fractions revealed the presence of Steroids (STR), Condensed Tannins (CDT), Cardiac Glycosides (CG) and Saponins (SAP). The HX4 fraction was the most potent, exhibiting complete inhibitory activity against all the fungal isolates tested. The fraction contained Anthraquinone Glycosides (ATG) with Retention factor (Rf) value of 0.87. All the PE fractions (PE1, PE2 and PE3) did not exhibit significant activity on the fungal isolates at 0.31 to 3.75 mg mL-1. The CHL fractions (CHL1 and CHL2) showed very high inhibitory activity on only Trichophyton mentagrophytes and Trichophyton rubrum. The phytochemical analysis of these fractions revealed the presence of CG, SAP, CDT and STR. The results of the present study add credence to the ethnomedicinal uses of Ficus sycomorus for the treatment of fungal diseases.
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