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Articles by U.K. Sandabe
Total Records ( 5 ) for U.K. Sandabe
  K.A. Sanda , U.K. Sandabe , F.A. Sanda , M.B. Tijjani , Y.B. Majama and B.G. Gambo
  Phytochemical screening of aqueous root extract of Leptadenia hastata was investigated in Maiduguri northern Nigeria, to evaluate the active component of the plant. Soxhlet extraction method was used to determine the phytochemical component of the extract. Saponins and flavonoids had high scores in the extract, alkaloids and pentoses had moderate scores, while tannins and ketones had low scores. Combined anthraquinones, free anthraquinones, reducing sugar, carbohydrates, glycosides and monosaccharides were not detected in the extract. In conclusion, Leptadenia hastata aqueous root extract contains pharmacologically active components which support its Ethno-botanical claims of traditional herbalist in Northern Nigeria in the treatment of various ailments.
  Y.G. Sabo , U.K. Sandabe , V.A. Maina and H.G. Balla
  Today prostaglandin and progesterone has been found widely used in several schemes of oestrus synchronization and controlled breeding program. Several controlled breeding program, have been developed for synchronizing groups of all open or lactating cows within a breeding group with or without ovarian palpation. Such programs are reviewed in this article which involves extending the luteal phase by treatment with exogenous progesterone such as: progesterone treatment regimes using syncro-mate-B, progesterone releasing intravaginal device, melengesterol acetate-select and melegestrol acetate plus prostaglandin. Also reviewed in the program is the termination of the luteal phase by treatment with prostaglandin or its analogues. These includes, controlled breeding without ovarian palpation such as, the 7-days program; 11-days program, target breeding, ovsynch program, Heat synch, Cosynch and pre synch-ovsynch program. In our opinion full potential of progesterone and prostaglandin for the detection of oestrus and timed artificial insemination should be utilized. This reduces the much labour input employed in previous years. The practitioner of the livestock herd health must-develop strategies for the delivery of this technology to livestock farmers, its use and limitations.
  F.I. Abdulrahman , P.A. Onyeyili , U.K. Sandabe and V.O. Ogugbuaja
  Aim of this study to investigate the effects of aqueous extract of Vitrex doniana on the peripheral and central nervous systems and possibility to use it as folk medicine. The aqueous extract of Vitex doniana was soxhlet extracted with distilled water and concentrated in vacuo to give a yield of 8.5% w/w. The LD50 following intraperitoneal administration was estimated to be 980 mg kgG1. The aqueous extract of Vitex doniana from the study produced substantial depressant effects on both the peripheral and central nervous system. The aqueous extract induced sleep on its own at dose of 400 mg kgG1 and potentiated sodium thiopental sleeping time in a dose dependant manner. It also showed significant (p< 0.05) muscle relaxant activities and produced analgesia and weal anesthetic effect. The extract was able to confer 80% protection to rats treated with convulsive dose of PTZ, while it conferred 100% protection to rats treated with convulsion dose of strychnine.
  K.A. Sanda , U.K. Sandabe , M.S. Auwal , I. Bulama , T.M. Bashir , F.A. Sanda and I.A. Mairiga
  This study was designed to evaluate the antidiabetic profile and the hypoglycaemic activity of aqueous root extracts of L. hastata in normal and alloxan-induced diabetic rats model. Eighty five albino rats were used for this study out of this thirty five were used subjected to experimental diabetes by the use of alloxan at a dose of 160 mg kg-1 body weight. Seven experimental groups of five rats per group (A-G) were used for this study. A standard antidiabetic drug (insulin) group (B) and normal saline group (G) serves as positive control. The blood glucose lowering activity of the extract, insulin and normal saline groups were monitored at 0, 1, 3, 6, 12 and 18 h post extract administration. On the other hand the remaining fifty albino rats were used to determine the acute toxicity and the hypoglycemic activity of the extract. The blood glucose levels of the rats were monitored at 0, 7, 14, 21 and 28 days post extract administration. Oral administration of aqueous root extract at 600 and 800 mg kg-1 b.wt have significantly (p<0.05) decreased the blood glucose in diabetic albino rats. On the other hand the hypoglycemic activity of the aqueous root extract on normal rats at dose of 1000 mg kg-1 b.wt have significantly (p<0.05) decreases blood glucose level in normal albino rats. The results of the current study have demonstrated the antidiabetic and hypoglycaemic effects of L. hastata aqueous root extracts and underscore its potentials in the management of diabetes mellitus especially following prolonged use in days.
  S.B. Aji , U.K. Sandabe and T.N. Egbe-Nwiyi
  In cognizance of the traditional use of the leaves extract of Olea hochstetteri Bak. against several diseases including non-insulin dependent diabetes mellitus, this study was carried out to determine the effect of prolonged oral administration of aqueous leaves extract of the plant on serum glucose and total cholesterol levels and body weight of rats. Sixty apparently healthy Wistar strain albino rats were separated into 4 equal groups (labeled A-D) and used in the experiment. Rats in groups B-D were given daily oral dose of 250, 500 and 1000 mg kg-1 of aqueous leaves extract of O. hochstetteri Bak., respectively for 21 days while those in group A served as control. At the end of each week, five rats from each group were humanely sacrificed to collect serum for analyses for glucose and total cholesterol. The body weights of the rats were also determined weekly. The result of the study revealed that the extract caused significant (p<0.05) decrease in serum glucose and total cholesterol and body weight of the rats throughout the period of treatment. It was concluded that the extract had hypoglycemic, anticholesterolemic and body weight lowering effects and may be potentially useful against diabetes mellitus, hypercholesterolemia and obesity. Further studies to elaborate more on these effects and on the toxicity of the plant were recommended.
 
 
 
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