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Articles by U.K. Patil
Total Records ( 3 ) for U.K. Patil
  A.N. Aher , S.C. Pal , S.K. Yadav , U.K. Patil and S. Bhattacharya
  The aim of the present study was to isolate the active constituents responsible for antioxidant activity. Radical scavenging activities of chromatographically isolated compounds from methanolic extracts of wood, bark, fruit and leaf were measured by the 1, 1-Diphenyl-2- Picrylhydrazyl (DPPH) method. The structures of isolated compounds were confirmed by spectroscopic techniques comprising of UV, IR, 13C NMR, P-NMR, Mass spectral and Co-TLC studies. The compound ANA 01, ANA 02 and ANA 04 were isolated from bark and confirmed as catechin, ellagic acid and gallic acid, respectively. The leaf extract resulted in separation of compounds ANA 03 (quercetin). The free radical scavenging activity of the different isolated compounds from methanolic extracts of Casuarina equisetifolia increased in a concentration dependent manner. ANA 04 (gallic acid) exhibited very strong antioxidant activity and when compared to ANA 01 (catechin), ANA02 (ellagic acid), ANA 03 (quercetin) and ANA05 (lupeol). This study suggests that the Casuarina equisetifolia could be pharmaceutically exploited for antioxidant properties.
  Alok Nahata , U.K. Patil and V.K. Dixit
  Shankhpushpi is a popular medicinal plant in the Ayurvedic system of medicine for treating mental disorders. Convulvulus pluricaulis Choisy. (Convulvulaceae) and Evolvulus alsinoides Linn. (Convulvulaceae) are used as Shankhpushpi by Ayurvedic practitioners. Ethanol extract of the aerial parts of both these drugs was evaluated for central nervous system (CNS) activity. The ethanol extract was fractionated into ethyl acetate and aqueous fractions and was tested in experimental models employing rats and mice. Elevated plus maze test, open field exploratory behavior and rotarod performance experiments were undertaken to observe influence on CNS. The extracts were also studied for their in vitro antioxidant potential to correlate their anxiolytic activity. In the elevated plus maze, ethyl acetate fractions of both the drugs at 100mg/kg per oral showed an anxiolytic effect as evidenced by increase in the time spent in open arms and the number of open arm entries, compared to the control group. The open field exploratory behavior was also increased on administration of the ethyl acetate fractions (100mg/kg p.o.) of both the drugs. The ethyl acetate fractions at doses of 200mg/kg p.o. significantly reduced the neuromuscular coordination indicative of the muscle relaxant activity at a higher dose in both the drugs. The aqueous fractions of both the drugs were devoid of the above pharmacological actions at similar doses. Diazepam (1mg/kg i.p.) was used as a standard in all the animal models studied. The present study provides scientific support for the anxiolytic and antioxidant activities of extracts of Evolvulus alsinoides and Convulvulus pluricaulis and substantiates the traditional claims for the usage of these drugs in stress-induced disorders.
  Deepa Iyer , B.K. Sharma and U.K. Patil
  Context: The papaya is the fruit of the plant Carica papaya L. (Caricaceae) used in India. Fruit and latex are both rich in an enzyme called papain. It is used as a folk remedy for contraception and abortion. Objective: The present study explored the anti-hyperlipidemic effect of the ether- and water-soluble fractions of C. papaya ethanol extract in olive oil-induced hyperlipidemic rats. The study also involved chromatographic studies of extract and fractions. Materials and methods: Flash chromatography was done for the most active fraction. The extract and fractions were administered orally at doses of 200 and 400 mg/kg body weight in rats. Olive oil (5 mL/kg oral dose) was administered 30 min after treatment. Blood was collected and centrifuged at 3000 rpm for 15−20 min and subjected to biochemical analysis. Result: The study dose-dependently inhibited the total cholesterol (TC), triglycerides (TG), low-density lipoproteins (LDL) level, and significantly increased high-density lipoprotein (HDL) level. Phytochemical screening revealed the presence of fats in the ether fraction, whereas the water fraction revealed the presence of tannins, alkaloids, glycosides. UV λmax was found to be 217 nm with a melting point of 41°C for the isolated component. Discussion and conclusion: The anti-hyperlipidemic effect was evaluated in olive oil-loaded rats. Acute treatment caused stimulatory effect on HDL level and inhibition in TC and TG elevation induced by olive oil. The extract and water fraction showed protective action by increasing the HDL cholesterol level.
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