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Articles by U.K. Karmakar
Total Records ( 3 ) for U.K. Karmakar
  U.K. Karmakar , S.K. Biswas , A. Chowdhury , S.Z. Raihan , M.A. Akbar , M.A. Muhit and R. Mowla
  The ethanol extract of Asparagus racemosus Willd was examined for antbacterial and antioxidant properties. Phytochemical investigation was also done to identify the presence of phytochemical compounds. The ethanol extract at the concentration of 500 μg disc-1 showed moderate antibacterial activity against Staphylococcus saprophyticus, Enterococcus faecalies, Streptococcus agalactiae and Escherichia coli with zone of inhibition of 7.77±0.37, 6.07±0.06, 10.10±0.11 and 6.00±0.04 mm, respectively while 250 μg disc-1 of the extract did not reveal any zone of inhibition against the tested bacterial strains. Antioxidant activity of the ethanol extract was determined according to their scavenging activity of the stable DPPH (1,1-diphenyl-2-picryl hydrazyl) free radical and 10% H2SO4. In the qualitative antioxidant assay, the extract showed free radical scavenging properties. Preliminary phytochemical analysis of the plant extract showed the presence of alkaloids, tannins, saponins, glycosides, flavonoids and carbohydrates which could be responsible for antibacterial and antioxidant properties justifying the ethnomedicinal applications of Asparagus racemosus. Thus, further advanced research is necessary to isolate and characterize the chemical compounds responsible for the therapeutic activities of the plant.
  S.K. Biswas , A. Chowdhury , J. Das , U.K. Karmakar , S.Z. Raihan , A.C. Das , M.A. Hannan , M.A. Monsur Dinar , M.J. Hassan , M.I. Hossain and M.R. Farhad
  Cuscuta epithymum Murr. (Convolvulaceae) is found in Bangladesh and has been used in traditional medicine. The present study was designed to investigate the preliminary phytochemical screening, cytotoxicity and antibacterial activities of the methanol extract of the plant stem. The preliminary phytochemical analysis was performed on the basis of the standard procedures and thin layer chromatography to confirm the presence of chemical compounds in the methanol extract of the plant. The minimum inhibitory concentration and cytotoxic activities of the extract were carried out according to broth dilution assay and brine shrimp lethality bioassay, respectively. The results of preliminary phytochemical analysis showed the presence of flavonoid, glycoside, alkaloids, carbohydrates, saponins and steroids in the plant extract. In this study, the methanol extract was subjected to Thin Layer Chromatography (TLC) in order to detect the phytoconstituents present in the extract and the best result of TLC was obtained from the solvent system comprising of toluene and ethyl acetate at the ratio of 5.5:4.5 which identified the maximum number of spots. Moreover, the extract showed moderate antibacterial activities against Bacillus megaterium, Pseudomonas aeruginosa, Escherichia coli and Salmonella typhi with MIC values of 4.96±0.20, 3.03±0.16, 3.47±0.20 and 4.07±0.08 mg mL-1, respectively. The methanol extract showed lethality against brine shrimp nauplii (LC50: 36.31 μg mL-1 and LC90: 83.18 μg mL-1 ). The results indicated that the methanol extract of the stem of the plant possessed antibacterial and cytotoxic properties with several numbers of chemical compounds.
  U.K. Karmakar , S.K. Sadhu , S.K. Biswas , A. Chowdhury , M.C. Shill and J. Das
  In ayurveda, Asparagus racemosus Willd is known as the queen of herbs because it has a strong rejuvenating, nurturing and stabilizing effect on excessive air, gas, dryness and agitation in the body and mind. Ethanol extracts of Asparagus racemosus (EEAR) belonging to the family Liliaceae was investigated for biological action. The present study was designed to evaluate the cytotoxicity, analgesic and antidiarrhoeal properties of the ethanol extract of whole plant of Asparagus racemosus. The test for analgesic activity of the crude ethanol extract was performed using acetic acid induced writhing model in mice. On the other hand, antidiarrhoeal test of the EEAR was done according to the model of castor oil induced diarrhoea in mice and brine shrimp lethality bioassay was used to determine the cytotoxic activity of ethanol extract of the plant. In acetic acid induced writhing in mice, the ethanol extract exhibited significant inhibition of writhing reflex 67.47% (p<0.01) at the dose of 500 mg kg-1 body weight. The plant extract showed antidiarrhoeal activity in castor oil induced diarrhoea in mice. It increased mean latent period and decreased the frequency of defecation with number of stool count at the dose of 250 and 500 mg kg-1 body weight, respectively comparable to the standard drug Loperamide at the dose of 50 mg kg-1 body weight. In addition to these, the brine shrimp lethality test showed the significant cytotoxic activity of the plant extract (LC50: 10 μg mL-1 and LC90: 47.86 μg mL-1). The obtained results support the traditional uses of the plant and require further investigation to identify the chemical constituent(s) responsible for cytotoxicity, analgesic and antidiarrhoeal activities.
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