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Articles by U.I. Nwagha
Total Records ( 3 ) for U.I. Nwagha
  E.E. Iyare and U.I. Nwagha
  The report that intervention during the juvenile-pubertal period in rats modifies the phenotype induced by prenatal nutrition suggests some degree of plasticity in the juvenile-pubertal period. It is not known whether consumption of aqueous extract of Hibiscus sabdariffa (HS) during the juvenile-pubertal period will affect the growth and onset of puberty in rats. The present study was therefore designed to investigate this. Weaned 21 days old rats, whose mothers were given food and water ad libitum during pregnancy and lactation, were divided randomly into three groups of nine rats each. Control group had tap water only while the extract groups had 0.6 g extract/100 mL and 1.8 g extract/100 mL as their drinking solution throughout the juvenile-pubertal period [postnatal day (PND) 21-puberty onset]. From PND 30 onwards, the rats were inspected daily for vaginal opening, which was used as the index for puberty onset. Rats in the HS groups (0.6 and 1.8 g/100 mL) drank less fluid (solution of HS extract and water) and consumed less food compared with the control group at all periods of measurement. The weight of 0.6 g/100 mL was not different from the control whereas 1.8 g/100 mL was lower at PND 28, similar at PND 35 and higher at PND 42 compared with the control. Puberty onset in the HS groups was significantly delayed compared with the control. It is concluded that consumption of aqueous extract of HS during the juvenile-pubertal period decreased fluid and food consumption, increased weight gain and delayed puberty onset in rats.
  E.E. Iyare and U.I. Nwagha
  This study investigated whether consumption of aqueous extract of Hibiscus sabdariffa during the juvenile-pubertal period will affect the BMI and visceral organ weights at onset of puberty in rats. Weaned 21 days old rats, whose mothers were given food and water ad libitum during pregnancy and lactation, were divided randomly into three groups of nine rats each. Control group had tap water only while the extract groups had 0.6 g-extract/100 ml and 1.8 g-extract/100 ml as their drinking solution throughout the juvenile-pubertal period (PND 21-puberty onset). All groups had normal rat chow and their respective drinking solutions ad libitum. From PND 30 onwards, the rats were inspected daily for vaginal opening, which was used as the index for puberty onset. Rats in the extract groups (0.6 g/100 ml and 1.8 g/100 ml) drank less fluid and consumed less food compared with the control group at all periods of measurement. The weight of 0.6 g/100 ml was not different from the control whereas 1.8 g/100 ml was lower at PND 28, similar at PND 35 and higher at PND 42 and at puberty onset compared with the control. Puberty onset in the extract groups was delayed and body weights and lengths, BMI, visceral organs weights and weight indices were higher in the extract groups. It is concluded that consumption of aqueous extract of Hibiscus sabdariffa during the juvenile-pubertal period decreased fluid and food consumption, increased BMI and visceral organs’ weights and may predispose to obesity at puberty onset in rats.
  S.A. Ufelle , E.O. Ukaejiofo , E.E. Neboh , P.U. Achukwu , U.I. Nwagha and S. Ghasi
  Bryophyllum pinnatumis a perennial herb growing widely and used in folkloric medicine. Much research has not been carried out on its effect on hematological parameters. We therefore, decided to investigate the effect of crude methanolic leaf extract of B. pinnatum on some hematological parameters in Wistar rats. Twenty male Wistar rats aged 2-3 months obtained from the Animal House of College of Medicine, University of Nigeria Enugu Campus were acclimatized for 2 weeks. They were divided into 5 groups labeled A-E. Groups A-D were orally fed with graded doses of the crude leaf extract (100, 200, 400 and 600 mg kg-1 b. wt., respectively) once daily for 28 days in lower concentrations compared to an oral LD 50 of 800 mg kg-1 b. wt. Group E served as control without receiving the extract. On day 29, about 2.5 mL of blood sample were collected from each rat through the median canthus into K3-EDTA anticoagulant containers for Hemoglobin (Hb), Packed Cell Volume (PCV), Total White Blood Cell (TWBC) and platelet count. The results revealed significantly increased Hb in all the treated groups, A = 15.9±1.0, B = 16.8±1.0, C = 17.5±1.0 and D = 18.7±1.0 g dL-1 when compared with control E = 13.5±0.5 g dL-1 (p<0.05). The PCV of the treated groups were also significantly increased, A = 0.48±0.01, B = 0.51±0.01, C = 0.53±0.01 and D = 0.56±0.01 L L-1 when compared with control E = 0.38±0.01 L L-1 (p<0.05). The TWBC were significantly increased in all the treated groups (A = 6.2±1.0, B = 6.5±1.0, C = 7.1±1.0 and D = 7.7±1.0x109 L-1 when compared with control E = 4.0±1.0x109 L-1. The platelet count were decreased in all the treated groups but was significant only in group A = 135±13x109 L-1 when compared with control E = 225±20x109 L-1 (p<0.05). The blood film examination revealed normocytic and normochromic red blood cells. This result pattern suggests that crude methanolic leaf extract of B. pinnatum may have properties that increase the Hb, PCV and TWBC while decreasing the platelets, hence care should be taken while consuming such extracts to avoid haematological disturbances such as thrombocytopaenia. Also, constant monitoring the hematological parameters should be ensured in subjects taking such medicinal herbs for whatever purposes.
 
 
 
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