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Articles by U.A. Osunkwo
Total Records ( 2 ) for U.A. Osunkwo
  A.T. Elsa , U.A. Osunkwo and P.A. Onyeyili
  The changes in electrical activity of the cerebral cortex during amylobarbitone anaesthesia were studied in rabbits. Electrical activity of the rabbit cerebral cortex recorded (using an oscilloscope), sixty minutes after induction of amylobarbitone (30 mg kg–1, body weight, I.P.) anaesthesia did not significantly differ from control values obtained before anaesthesia or 24 h after recovery from anaesthesia. Amylobarbitone administered @ 60, 90 and 120 mg kg–1 body weight significantly (P<0.05) and dose - dependently decreased the cerebral electrical activity. Therefore, amylobarbitone at the dose of 60 mg kg–1 body weight or higher may cause depression in the electrical activity of the rabbit brain.
  G.C. Akuodor , C.C. Mbah , A.D. Essien , J.L. Akpan , B.C. Ezeokpo , T.C. Iwuanyanwu and U.A. Osunkwo
  Bridelia ferruginea which have some ethnomedicinal applications was investigated for ulcer-protective and anti-diarrhoeal effects. The ulcer-protective and anti-diarrhoeal activities of the aqueous stem bark extract were examined in rats and mice. Acute toxicity studies were also carried out. The extract exhibited ulcer-protective properties against ethanol and indomethacin induced ulceration activity in rats with maximal anti-ulcer activity observed at 400 mg kg-1. The extract dose dependently decreased intestinal propulsion of charcoal meal in mice. The aqueous extract of Bridelia ferruginea also exerted significant anti-enteropooling in mice. A significant antidiarrhoeal activity was also recorded in mice. The frequency of defaecation as well as the wetness of faecal droppings was reduced. In addition, the extract produced 100% inhibition of castor oil-induced diarrhoea in mice. The oral LD50 obtained was greater than 5000 mg kg-1 in mice. The results show that Bridelia ferruginea stem bark probably contains some active ingredients that potentially could be developed as useful drug for the treatment of ulcer and diarrhoea in Nigerian herbal traditional medicine.
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