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Articles by U. Nanthini
Total Records ( 2 ) for U. Nanthini
  S. Fakurazi , U. Nanthini and I. Hairuszah
  This study is conducted to investigate the possible hepatoprotective action of Moringa oleifera Lam. (MO), a high value medicinal plant against a single high dose of APAP induced hepatotoxicity. Male Sprague Dawley rats were dosed with APAP (3000 mg kg-1 body weight; p.o.) to induce hepatocellular damage. In rats that were pretreated with MO (200 and 800 mg kg-1; p.o.) for 14 days prior to APAP treatment, there was a reduction of liver enzymes (ALT, AST and ALP) and also the restoration of glutathione level. The biochemical results showed parallel finding with the histopathological analysis in which liver sections obtained from rats pretreated with MO, the damage was blocked. Intriguingly, MO alone has significantly elevated the level glutathione compared to the control group. The findings has suggested that Moringa oleifera Lam. is a promising product in protecting the liver against APAP induced liver injury via the restoration and elevation of glutathione level in the liver.
  S. Fakurazi , I. Hairuszah , J. Mohd Lip , G. Shanthi , U. Nanthini , A.R. Shamima , H. Roslida and Y.H. Tan
  This study is conducted to investigate the possible effect of zerumbone towards hepatoprotective activity against paracetamol intoxication. Male Sprague-Dawley rats were randomly divided into six groups consisted of 3-5 animals. Group I was administered with 0.2% zerumbone for 14 days prior to 3 g kg-1 paracetamol administration. Group II was given paracetamol only and group III was given 200 mg kg-1 of silymarin and paracetamol. Group IV was administered with zerumbone only and finally group V was treated with corn oil and 40% sucrose buffer as vehicle treated group. Animals were sacrificed at 4 and 24 h post treatment following diethyl ether. There was no significant changes in liver enzyme activities as well as histological observations at 4 h after paracetamol administration. Meanwhile, 24 h after paracetamol administration, the level of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were found to be reduced in rats that were pretreated with zerumbone compared to group that was treated with paracetamol only. Correspondingly, there was no hepatocellular necrosis observed in rats that were pretreated with zerumbone. The results obtained may have suggested that zerumbone exert hepatoprotective activities against paracetamol induced hepatotoxicity.
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