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Articles by U. Bose
Total Records ( 2 ) for U. Bose
  V. Bala , A. Debnath , A.K. Shill and U. Bose
  The ethanolic extract of the dried aerial parts of Mucuna pruriens Linn. (Fabaceae) was investigated for its possible anti-inflammatory, diuretic and antibacterial activities in animal models. Anti-inflammatory activity was tested using carrageenin induced rat paw edema model and cotton pellet implantation method in rat. Diuretic activity was measured by the comparison of control group, standard drug group (furosemide) at a dose of 0.5 mg kg-1 and the sample extracts 200 and 400 mg kg-1, respectively. The antibacterial property was studied by the disc diffusion method using extract 200 mg disc-1. The extracts significantly (p<0.001) reduced carrageenin induced paw edema in rats. Cotton pellet implantation model for antiinflammatory activity, the extract showed a significant reduction in the weight of the cotton pellet in test animal compared to control (p<0.001). At the doses of 200 and 400 mg kg-1, the extract exhibited 24.59 and 33.41% reduction of the weight of the cotton pellets. Diuretic activity was proved by the electrolyte loss ratio (Na+/K+ excretion ratio was 1.48 and 1.45 at the doses of 200 and 400 mg kg-1, respectively) as that of the standard diuretic furosemide (1.47). The extracts also showed the antibacterial activity against eight species of bacteria. The results obtained shows that the extracts of Mucuna pruriens Linn. has anti-inflammatory, diuretic and antibacterial properties. This finding provides a basis for the traditional use of the plant material.
  U. Bose , K. Gunasekaran , V. Bala and A.A. Rahman
  The crude methanol extract of the roots of Dillenia indica Linn. (Family: Dilleniaceae) was investigated for its possible analgesic, antidiarrhoeal and GI motility tests in animal models. The extract produced significant writhing inhibition in acetic acid-induced writhing in mice at the oral dose of 250 and 500 mg kg-1 b.wt. (p<0.01) comparable to the standard drug diclofenac sodium at the dose of 25 mg kg-1 of body weight. The crude extract produced significant antidiarrhoeal effect at the dose of 500 mg kg-1 of body weight comparable to that produced by loperamide, used as standard drug. The extract also reduced significantly the charcoal induced Gastro Intestinal (GI) motility in mice; decreased the movement of GI tract in comparison to control animals. This study has found a base stone to step ahead for further researches to make them pharmaceutically useful.
 
 
 
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