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Articles by U. Akpamu
Total Records ( 7 ) for U. Akpamu
  O.I. Iribhogbe , U. Akpamu , J.E. Emordi , A. Aigbiremolen , E.O. Nwoke and B. Idinoje
  The effect on electrolyte profile following oral administration of antioxidants (vitamin A, C and E supplements in early pregnancy was investigated using albino rats of the Wistar strain. Eighty-five female rats weighing between 255-300 g were used for the study. They were randomly assigned to three study groups having 5 sub groups with five animals each, a control and vehicle group with five animals each. After pregnancy has been confirmed, the control group was administered 1 mL of distilled water, vehicle group 1 mL of tween 80, while test groups 1, II and III received different doses of vitamin A, C and E, respectively via the intragastric route for 11 days. The administration of vitamin A, C and E in early pregnancy for 11 days produced insignificant changes in serum Na+ levels (p>0.05) and a significant increase in serum Ca2+ level. With the exception of vitamin C, vitamin A and E produce a significant increase in serum K+ and Cl¯ levels. Conclusively administration of vitamin A, C and E in early pregnancy cause no significant alteration in serum Na+ levels. However, care must be taken when vitamin A and E are administered with agents that elevate serum Ca2+ and K+ levels as this may pontentiate hypercalcemia and hyperkalemia, respectively in early pregnancy.
  O.B. Idonije , O. Festus , O. Okhiai and U. Akpamu
  Malaria infection has been found to be associated with lipid peroxidation accompanying reduction in antioxidant capacity of the infected patients especially Plasmodium falciparum infection. In this study, a biomarker of lipid peroxidation, Malondialdehyde (MDA) was evaluated in adult (18-45 years) Nigerian patients with Plasmodium falciparum and Plasmodium vivax malaria infection. The research group is comprised of fifty patients with P. falciparum and fifty with P.vivax malaria confirmed patients attending the outpatient department of University of Benin Health Services Department, University of Benin, Benin City. Their lipid peroxidation products (MDA) values estimated spectrophotometrically were compared to that of the control group who are fifty apparently healthy tested malaria negative subjects. Result showed a significant increase (p<0.05) in Malondialdehyde level in malaria positive patients (n = 100; 7.67±0.42 μM L-1) compared to the control; malaria negative patients (n = 50; 4.43±0.32 μM L-1). This increase in Malondialdehyde level was higher in P.vivax malaria patients (n = 50; 7.94±0.27 μM L-1) than in P. falciparum malaria (n = 50; 7.41±0.38 μM L-1) and increases as the degree of parasitaemia increases. Malondialdehyde activity in malaria was higher in males than in females and among the young adults than in the old adults. The study specified malaria to induced oxidative stress which is higher in male and in the young and as the degree of parasitaemia increases and more severe with P.vivax malaria infection. Conclusively, supplementation of diet with antioxidants along anti-malaria drugs during treatment of malaria patients is recommended.
  C.N. Ekhato , U.C. Osifo and U. Akpamu
  Earlier investigators have reported early Oral Contraceptives Pills (OCPs) to be hepatotoxic. Despite the modifications on early OCPs in term of content and dosage to lessen their side effects, paucity of literatures existed on the effects of newer OCPs on liver function and integrity. This study is designed to investigate the effect of OCP containing low doses of synthetic hormones on liver function and integrity. The study involves 15 adult female rabbits, divided into three groups (A, B and C). Group A serves as the control, while B and C served as the test groups involving lower and higher weight rabbits respectively. Throughout the period of the study water, rabbit feed and grasses were given ad libitum to animals in each group. In addition, animals in group B and C received for 7 and 14 days; 0.14 and 0.3 mL kg-1 b.wt. of OCP, respectively. At the end of the experiment, blood sample was collected for the analysis of liver function parameters. The results showed progressive increase in all the parameters studied in test group (B and C) compared to control (group A). Specifically, there were significant increases in total bilirubin, AST and ALT between the groups. While group B presented a non significant increase in direct bilirubin, total protein and ALP compared with control values, group C presented significant increase in these parameters compared to control and test group B. The results of this study therefore suggest that OCP regardless of their dosages, have potentials for impairing liver function and may induces liver damage.
  O.I. Iribhogbe , A. Aigbiremolen , U. Akpamu , J.E. Emordi and E.O. Nwoke
  The purpose of this study is to evaluate the effects of vitamin A, C and E supplementation on lipid profile in early pregnancy. A total of 85 adult female wistar albino rats weighting 225-300 g were used and randomly grouped into 5 groups (2 control groups of five rats each, 3 test groups with 5 sub- groups of 5 rats each). After, pregnancy was confirmed, the control groups were administered distilled water and tween 80 respectively, while test groups A, C and E received vitamin A, C and E supplements, respectively. At the end of the 11th day of the experiment, blood samples were collected and TC (total cholesterol), TG (Triglyceride), LDL-C (low density lipoprotein cholesterol and HDL-C (high density lipoprotein cholesterol) were assayed using standard procedure. The test group had significantly increased TC, LDL- C and HDL- C but decreased TG levels following vitamin A administration when compared with control (p<0.05). The group supplemented with vitamin C also had significantly higher TC, TG and LDL- C and unchanged HDL-C compared with control (p<0.05). The group supplemented with vitamin E had a non significant TC levels, a significantly increased TG and HDL- C and a significantly reduced LDL- C levels (p<0.05). Based on results observed, we suggest that, in pregnancy, dietary supplementation with Vitamin A and E may be cardioprotective. This is because vitamin A and E significantly increase HDL- C, although this is accompanied by increase of other serum lipid component. Vitamin C, however was not beneficial.
  O.I. Iribhogbe , J.E. Emordi , E.O. Nwoke , B.O. Idonije and U. Akpamu
  The purpose of this present study is to determine the influence of varying combinations of antioxidant Vitamins on the hyper-hepatic state of pregnancy. To achieve this, seventy pregnant Wister albino rats weighing between 250-300 g were procured and grouped into 2 control groups treated with distilled water and vehicle- tween-80, respectively and three cohorts (I, II and III) with four sub-groups each (n = 5). Starting from the 7th day, group I received a varying dose combination of Vitamin A+C, group II Vitamin A+E and group III Vitamin C+E respectively for 11 days. Results of liver function assay revealed that supplementation with Vitamin A+C, A+E and C+E caused a significant reduction (p<0.05) in serum protein and a non-significant (p>0.05) alteration in serum albumin. Except for ALT where Vitamin A+E combination produced no significant alteration, serum AST (Aspartate transaminase) and ALP (Alanine transaminase) were significantly reduced (p<0.05) with antioxidant Vitamin combination therapy when compared with control. Antioxidant vitamin combination may be advantageous in pregnancy induced hyper- hepatic state. However, further study is needed in this respect.
  O.B. Idonije , O.O. Festus , U. Akpamu , O. Okhiai , O.I. Iribhogbe and G.B.S. Iyalomhe
  Although antipsychotic drugs are known to have an array of adverse effects, they also exhibit significant differences in causing these effects. The atherogenic effects of clozapine and risperidone have not been fully investigated among schizophrenics in Nigeria hence this research work. This study therefore investigated the extent to which monotherapy with clozapine and risperidone (atypical antipsychotic drugs) influence lipid profile in patients with schizophrenia. The study population comprised 29 Schizophrenic patients from Psychiatric Hospital, Uselu, Benin city, Nigeria. They were placed on typical antipsychotics for six weeks: 10 patients were on risperidone (1-4 mg day-1 in divided doses) and 19 patients were on clozapine (25-300 mg day-1 in divided doses). The control group comprised 30 apparently healthy volunteers. Blood samples were collected from all subjects on the first day before the commencement of treatment with antipsychotic drug and 24 h after the last administration of antipsychotics at the end of week 6 for analyses of total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol (LDL) and very low density Lipoprotein cholesterol (VLDL) using standard methods. Comparing with the control, the basal serum TC, TG, LDL and VLDL of the clozapine treated group were not significantly different except for HDL which was significantly reduced and the atherogenic indices (TC/HDL and LDL/HDL) which were significantly increased. However the risperidone treatment group showed significantly higher TC, TG, LDL and VLDL levels while HDL was significantly reduced. At the end of week 6, there was significant increase in serum TC, TG, HDL and VLDL and a significant decrease in HDL in both treatment groups compared to the control except VLDL that was not significantly different in the clozapine group. Comparing the two treatment groups, risperidone caused a more significant increase on lipid profile and atherogenic indeces than clozapine. This effect was about two times or greater with risperidone than clozapine. Conclusively, additional prospective clinical trials are required to support a specific therapeutic approach for managing dyslipidaemia that are present in clozapine and risperidone treated schizophrenic patients in an attempt to avoid its consequent adverse effects.
  C.N. Ekhator , A. Omorogiuwa and U. Akpamu
  Despite the modifications on Oral Contraceptive Pills (OCPs) in term of content and dosage to lessen their side effect, paucity of information existed on the effect of COCP on kidney function. Hence, this study investigates the effect of COCP containing 0.15 mg levonorgestrel (a progestogen) and 0.03 mg ethinylestradiol (an estrogen) on kidney biochemical parameters and electrolytes. The study involves 15 female rabbits divided into three groups (A, B and C). Group A served as the control, while B and C served as the test groups and were administered the COCP per body weight human doses for 7 and 14 days, respectively. At the end of the study, blood sample was obtained for the determination of plasma creatinine, urea, Na, Cl and K using standard laboratory procedures. Results showed significant increase (p<0.05) in plasma creatinine, urea and K+ but a decreases in plasma Na+ and Cl¯ in the tests compared to the control. Considering the observed changes in the parameters herein studied, COCPs usage is not without impact on kidney function and may cause homeostasis dysfunction and hence the need for further studies.
 
 
 
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