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Articles by Tuo Karim
Total Records ( 1 ) for Tuo Karim
  Offianan André Toure , Tuo Karim , Beourou Sylvain , Koffi David , Djaman Allico Joseph and Coulibaly Adama
  Background and Objective: Resistance of human malaria parasites to anti-malarial compounds has become a considerable concern. Investigating plants used in traditional medicine to treat malaria remains a credible option for new anti-malarial drug development. The aim of this study was to evaluate extracts from two medicinal plants, Diospyros monbuttensis and Newbouldia laevis, used in traditional medicine in Côte d’Ivoire, for in vitro antiplasmodial activities. Materials and Methods: SYBR GREEN fluorescence method was used to evaluate the in vitro inhibitory activity of the extracts, chloroquine, artesunate and quinine against Plasmodium falciparum field isolates and two laboratory strains of Plasmodium falciparum : the chloroquine sensitive 3D7 and the chloroquine resistant Dd2. Chloroquine, quinine and artesunate have been selected as the reference anti-malarials in comparison to plant extracts. In addition, the haemolytic activity of extracts with good antiplasmodial activity was evaluated. The IC50 and the corresponding correlation coefficients were determined graphically using in vitro Analysis and Reporting Tool (IVART) software of WWARN. Results: Methanol crude extract of Newbouldia laevis showed promising activity against field isolates and reference parasites while Diospyros monbuttensis had moderate antiplasmodial activity. The liquid-liquid partition has significantly improved antiplasmodial activity with F3 fraction of Newbouldia laevis. There was less than 1% hemolysis at the concentration of 200 μg mL1 of plant extracts. Conclusion: These results validate the reported traditional use of Diospyros monbuttensis and Newbouldia laevis for malaria treatment in Côte d’Ivoire.
 
 
 
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