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Articles by Tuo Karim
Total Records ( 2 ) for Tuo Karim
  Offianan André Toure , Tuo Karim , Beourou Sylvain , Koffi David , Djaman Allico Joseph and Coulibaly Adama
  Background and Objective: Resistance of human malaria parasites to anti-malarial compounds has become a considerable concern. Investigating plants used in traditional medicine to treat malaria remains a credible option for new anti-malarial drug development. The aim of this study was to evaluate extracts from two medicinal plants, Diospyros monbuttensis and Newbouldia laevis, used in traditional medicine in Côte d’Ivoire, for in vitro antiplasmodial activities. Materials and Methods: SYBR GREEN fluorescence method was used to evaluate the in vitro inhibitory activity of the extracts, chloroquine, artesunate and quinine against Plasmodium falciparum field isolates and two laboratory strains of Plasmodium falciparum : the chloroquine sensitive 3D7 and the chloroquine resistant Dd2. Chloroquine, quinine and artesunate have been selected as the reference anti-malarials in comparison to plant extracts. In addition, the haemolytic activity of extracts with good antiplasmodial activity was evaluated. The IC50 and the corresponding correlation coefficients were determined graphically using in vitro Analysis and Reporting Tool (IVART) software of WWARN. Results: Methanol crude extract of Newbouldia laevis showed promising activity against field isolates and reference parasites while Diospyros monbuttensis had moderate antiplasmodial activity. The liquid-liquid partition has significantly improved antiplasmodial activity with F3 fraction of Newbouldia laevis. There was less than 1% hemolysis at the concentration of 200 μg mL1 of plant extracts. Conclusion: These results validate the reported traditional use of Diospyros monbuttensis and Newbouldia laevis for malaria treatment in Côte d’Ivoire.
  N'Docho Assi Fiacre-Tanguy , Tuo Karim , N'Guessan Tiacoh Landry , Kassi Kondo Fulgence , Koffi Attoungbré Clément , Fofana Mamery , Kouamé Amani Casimir , Messou Kouassi Eugène , Assoua Messou Anicet-Charles , Bialé Marina Danielle Datcho-Gouenet Ayaud , Kragbé Daugbley Guy Roland , N'Guetta Essan Jean Jacques , Oyebi Mukayila , Dadié Ettawa Alponse , Ronan Jambou , Vanga Bosson Abo Henriette , Gonédélé Bi Sery Ernest and Touré Offianan André
  Background and Objective: Intestinal coccidia is one of the main causes of diarrheal infections among people living with HIV (PLHIV). The occurrence of diarrhoea in PLHIV affects their health status. The purpose of this study was to determine the prevalence of intestinal coccidia in patients with HIV/AIDS and to investigate a possible correlation between these parasites and the CD4 count in patients. Materials and Methods: This was a cross-sectional study carried out in three health care centres of PLHIV in Abidjan. Socio-demographic, clinical and biological data were collected using a questionnaire. Stool and blood samples were collected. Parasitic coprology analysis included the direct microscopic examinations, the concentration techniques (Ritchie and kato-katz) and Ziehl Neelsen. The last one allowed the detection of the oocysts of the coccidia. Results: A total of 363 faecal samples were collected from 03 health care centres. The stool samples collected consisted of 47.65% of diarrhoea. The results of the microscopic analysis revealed 03 intestinal coccidia's namely Cryptosporidium spp. (3.86%), Isospora spp. (1.65%) and Cyclospora spp. (0.83%). The highest microscopic prevalence was recorded in Cryptosporidium spp. (3.86%). Intestinal coccidia was more common in females infected with type 1 of HIV. CD4 count was a significant factor in the occurrence of Cryptosporidium spp. (χ2 = 29.968, p-value = 0.0001) with a correlation coefficient of -0.2438. Conclusion: This study assessed the microscopic prevalence rates of intestinal coccidia, which are responsible for diarrheal disease among PLHIV. The current study also showed that the presence of these intestinal coccidia's could affect the immune system of PLHIV when the CD4 cell count is below 200 cells mm–3.
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