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Articles by Tsala David Emery
Total Records ( 2 ) for Tsala David Emery
  Bella Ndzana Martin Thierry , Tsala David Emery , Ngo Lemba Tom Esther , Aboubakar Oumarou Bibi Farouck , Bilanda Danielle Claude and Dimo Theophile
  The stem bark of Tetrapleura tetraptera (Taub) [Mimosaceae] is used in cameroonian ethnomedicine for the treatment of hypertension and diabetes. This experiment was conducted to evaluate the possible effects of Tetrapleura tetraptera Aqueous Extract (TAQE) against hypertension and investigate its antioxidant effect in salt-induced hypertensive rats. High-salt hypertensive rats (9%) received vehicle (distilled water, 10 mL/kg/day), TAQE (100 or 200 mg/kg/day) or captopril 20 mg/kg/day. After a period of 4 weeks, Systolic Blood Pressure (SBP) was measured by invasive method. The lipid profile, oxidative status and liver function were evaluated by colorimetric method. There were significant rise in SBP and heart rate in salt treated rats. The malondialdehyde and antioxidative enzymes (catalase and superoxyde dismutase) levels were significantly elevated and decreased respectively in high salt as compared to control. The oral co-administration of TAQE with high salt reduced the SBP and improved the antioxidant status, lipid profile and liver function. Captopril associated with high salt prevented the some alterations induced by salt consumption in rats. This study supports the traditional used of Tetrapleura tetraptera against hypertension. Tetrapleura tetraptera could prevent the rise in blood pressure and improved the oxidative status in salt model of hypertension.
  Bella Ndzana Martin Thierry , Ngo Lemba Tom Esther , Aboubakar Oumarou Bibi Farouck , Tsala David Emery and Dimo Theophile
  Background: Tetrapleura tetraptera (Schumach and Thonn) Taub stem bark is used in African folk medicine to treat hypertension. In the present study, the antihyperlipidemic and antioxidant effects of Tetrapleura tetraptera aqueous extract was investigated in high salt-sucrose-induced hypertensive rats. Methods: Hypertensive rats were obtained from normotensive Wistar rats by giving daily, 2 mL/100 g salt solution (9%) p.o., with free access to sucrose solution (10%) as drinking water. Another set of rats were divided into three groups of five rats each and treated respectively with salt-sucrose and the aqueous extract of Tetrapleura tetraptera (100 and 200 mg kg-1) or captopril (20 mg kg-1). The effects of plant extract were evaluated after 3 weeks on blood pressure, lipid profile, oxidative status and liver function of animals and compared to those of normotensive control rats. Blood pressure was evaluated by invasive method and biochemical parameters were evaluated by colorimetric and kinetic methods. Results: Chronic salt-sucrose consumption increased systolic arterial blood pressure (30.05%) and heart rate (15.36%) as compared to control. Tetrapleura tetraptera aqueous extract (100 and 200 mg kg-1) or captopril significantly prevented the increase in blood pressure and heart rate and inhibited salt-sucrose-induced lipid peroxidation in the liver. Tetrapleura tetraptera countered salt-sucrose induced oxidative stress by enhancing the activity of antioxidant enzymes (catalase, superoxide dismutase) and glutathione content. The plant extract significantly reduced the high concentration of serum Total Cholesterol (TC), glucose, triglyceride (TG) and low density lipoprotein (LDL-C) and increased high density lipoprotein (HDL-C) observed in salt-sucrose hypertensive rats. Tetrapleura tetraptera also prevented the increase in atherogenic index. Conclusions: these finding supports the traditional use of Tetrapleura tetraptera extract and suggested that the bark of this plant could protect from salt-sucrose damage by enhancing activities of enzymes and holding up the increase of lipid markers and membrane peroxidation.
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