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Articles by Trey Hutton
Total Records ( 1 ) for Trey Hutton
  Dhiraj Vattem and Trey Hutton
  Oxidative stress has been linked to several chronic diseases, including heart disease and cancer. Phenolic phytochemicals abundant in natural products have high antioxidant activity and can potentially reduce the effects of oxidative stress. However, their antioxidant response mechanism in vivo is not very well understood. Present objective was to investigate the effect of several natural products on modulating the antioxidant response in vivo in Hydrogen Peroxide (HP) stressed Lumbricus terrestris. Sexually mature L. terrestris were randomly divided into 4 treatment groups and were allowed to feed ad libitum on 1.25% Gerber-oatmeal Agar (GA). The animals in control, peroxide, treatment and treatment-peroxide groups, fed on GA, GA+0.13% HP, GA+10% extract and GA+0.13% HP+10% extract, respectively. Two animals from each group were euthanized after 2 d, 4 d and 6 d and 1 inch of circular muscle posterior to the clitellum was dissected and extracted. Malondialdehyde (MDA) levels were determined to assess peroxide induced lipid oxidation. The antioxidant response was determined by measuring the radical quenching activity of muscle, the levels of Superoxide Dismutase (SOD) and Catalase (CAT) using standard methods. Present results indicated that compared to controls, animals on grapefruit, grape, ginger and cranberry diet had the lowest MDA levels and high radical quenching activity. Animals on grapefruit, ginger, raspberry and cranberry diet had 3-7 fold more muscle CAT levels. SOD levels in animals on turmeric, mace, blackberry and oregano diet was almost 100-200 fold higher. Our results suggest that dietary phytochemicals can manage acute oxidative stress in vivo by inducing antioxidant enzyme response mediated by SOD and CAT.
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