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Articles by Tijen ONKOL
Total Records ( 2 ) for Tijen ONKOL
  Deniz S. DOGRUER , Tijen ONKOL , Semiha OZKAN , Selda OZGEN and M. Fethi SAHIN
  Some 3(2H)-pyridazinone and 1(2H)-phthalazinone derivatives were synthesized. The structures of these new compounds were confirmed by IR, 1H-NMR, mass spectrum, and elemental analysis. The synthesized compounds were evaluated for their antibacterial activity against various gram-positive and gram-negative strains of bacteria and their clinical isolates and for their antimycobacterial activity against M. tuberculosis H37Rv. The results showed that the synthesized compounds were generally active against B. subtilis and its clinical isolate. Among the target compounds, compound 14c exhibited the best antibacterial activity, with a MIC value of 15.62 m g/mL against B. subtilis. Compound 15e had the highest antimycobacterial activity.
  Deniz S. DOGRUER , Solen URLU , Tijen ONKOL , Berrin OZCELİK and M. Fethi SAHIN
  Some pyridazine derivatives carrying urea, thiourea, and sulfonamide groups were synthesized and evaluated for their antimicrobial activity against gram-positive and gram-negative bacteria, and fungi by using broth microdilution. The structures of these new compounds were confirmed by 1H-NMR, mass spectrum, and elemental analysis. The synthesized compounds exhibited generally promising inhibitory activity against S. aureus (MIC ranging from 2 to 4 μ g/mL) and E. coli (MIC ranging from 4 to 16 μ g/mL). Moreover, all compounds showed antifungal activity against both C. albicans and C. parapsilosis, with a MIC value of 8 μ g/mL.
 
 
 
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