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Articles by Thierry Sulpice
Total Records ( 3 ) for Thierry Sulpice
  A. Lemhadri , Mohamed Eddouks , Thierry Sulpice and Remy Burcelin
  This study was undertaken in order to evaluate the possible anti-hyperglycaemic and body weight reducing activities of the aqueous extract of both Capparis spinosa (CS) and Chamaemelum nobile (CN) (20 mg kg-1). The results demonstrate clearly that repeated oral administration of both CS and CN aqueous extract evoked a potent anti-hyperglycaemic activity in high fat diet (HFD) obese mice. Postprandial hyperglycaemic peaks were significantly lower in plant-treated experimental groups. In other hand, body weight was significantly lower in CS and CN-treated groups when compared to the control one after daily oral administration of CS and CN aqueous extracts for 15 days.
  Zeggwagh Naoufel Ali , Mohamed Eddouks , Jean Baptiste Michel , Thierry Sulpice and Lhoussain Hajji
  This study aims to evaluate the hypotensive activity of Capparis spinosa Aqueous Extract (CSAE) in Spontaneously Hypertensive (SH) rats. CSAE was lyophilised and administrated daily at a dose of 150 mg kg-1 for 20 days. CSAE administration produced a significant reduction in systolic blood pressure after eight days of oral administration (p<0.01), a sustained reduction was observed at the end of the end treatment (p<0.01). Heart rate remained unchanged during 20 days of CSAE oral administration. In addition, CSAE administration produced a significant increase in urinary output (p<0.01) and Glomerular Filtration Rate (GFR) (p<0.01) at the eighth day of treatment. Urinary electrolytes excretion was also modified during 20 days of CSAE administration, a significant increase in urinary sodium and potassium excretion was observed from the fourth day (p<0.01) to twentieth day (p<0.001). However, urinary chloride excretion was increased from the eighth day (p<0.01) to the end of treatment (p<0.001). The observed hypotensive effect seems to be independent of renin angiotensin system since the CSAE did not modify the plasma angiotensin converting enzyme and renin activities (p>0.05) after 20 days of oral administration. We conclude that CSAE possess antihypertensive activity in SH rats and the underlying mechanism seems to be mediated via at least an increase in urinary and electrolytes output.
  Lemhadri Ahmed , Remy Burcelin , Thierry Sulpice and Mohamed Eddouks
  The present study was undertaken in order to evaluate the possible mechanisms of action involved in the hypoglycaemic activity of the aqueous extract of Chamaemelum nobile (CN) (20 mg kg-1). This study was carried out in Multi Low-Dose Streptozotocin-induced (MLDS) diabetic mice. Hypoglycaemic effect of CN was studied after both single and repeated oral administration of CN aqueous extract (20 mg kg-1). Endogenous glucose production was estimated using primed-continuous 3-3H glucose infusion technique. While, euglycemic hyperinsulinemic glucose clamp technique was used to assess peripheral insulin sensitivity. Both single and repeated oral administration (s) of aqueous CN extract evoked a prominent hypoglycaemic activity in MLDS diabetic mice. In other hand, 3-3H glucose infusion demonstrated that this hypoglycaemic activity was accompanied by a decrease in basal endogenous glucose production (EGP). EGP was lower in CS-treated group when compared to the control group, 15.5±0.5 vs 27.2±7.1 mg kg-1 min-1 (p<0.001) respectively. While, the metabolic clearance rate of glucose remains unchanged. In addition, we have demonstrated that CN treatment also improves insulin sensitivity in peripheral tissues, suggested by the observed higher levels of the glucose infusion rate. We can conclude that inhibition of basal endogenous glucose production and amelioration of insulin sensitivity in peripheral tissues account for the hypoglycaemic activity of aqueous CN extract in MLDS diabetic mice.
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