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Articles by Thangavel Sivakumar
Total Records ( 2 ) for Thangavel Sivakumar
  Manoj Ramesh Kumbhare , Thangavel Sivakumar , Tanuj Lakhote and Pravin Govinda Morankar
  Moringa oleifera (Moringaceae) is a bush of African savannah, commonly known as Drum stick used in folk Medicine for the treatment of rheumatic pain, analgesic activity, antipyretic activity. The aims of present study were Evaluation of Membrane Stabilizing Potential and Antimicrobial Activity stem bark of Moringa oleifera (Moringaceae) against Selected Microbes. In Diffusion assay (Plate method) of extracts of M. oleifera depends on the diffusion of an antibiotic from a vertical cylinder or cavity through the solidified agar layer of petri plate to an extent such that growth of added microorganism is presented entirely in circular area or “zone” around the cavity. In this method zone of inhibition is determined. HRBC membrane stabilization method used for evaluation of in vitro anti-inflammatory activity. The results of HRBC Stabilization in vitro anti-inflammatory activity of Moringa oleifera of extracts showed good inhibitory activity in petroleum ether extract as % inhibition of Haemolysis 5, 12, 20 and 33% in 10, 25, 50 and 100 μg mL-1 concentration, respectively. Chloroform extract and methanol extracts of Moringa oleifera showed moderate to good zone of inhibition against selected microorganisms compared with standard as Gentamicin. Analgesic and anti-inflammatory effects of flavonoids, steroids and tannins have been reported hence the anti-inflammatory effect produced by these extracts may be predictable due to the flavonoids and steroids. The HRBC membrane stabilizing property of Moringa oleifera was found to be promising and also exhibited good antimicrobial activity.
  Manoj Ramesh Kumbhare and Thangavel Sivakumar
  Background and Objective: Type 2 Diabetes Mellitus is a long term endocrine metabolic disorder that is described by elevated blood sugar, insulin resistance and deficiency of insulin. Due to low toxicities and cost effectiveness natural products are comparatively safe and good source of effective antidiabetic agents. The present study designed to evaluate the effects of Caesalpinia pulcherrima extracts on blood glucose in normal and alloxan monohydrate-induced diabetic rats. Materials and Methods: Albino rats of Wistar strain (150-200 g) of either sex were used in the entire study. After randomization into various groups and before initiation of experiment, the rats were acclimatized for a period of 7 days under standard environmental conditions of temperature, relative humidity and dark/light cycle. Animals described as fasting were deprived of food for 16 h and water ad libitum. Sample collection-blood samples were collected by retro-orbital plexus puncture method and blood glucose levels were estimated using an electronic glucometer. Results: Three weeks of daily treatment of Alloxan induced methanolic extract of Caesalpinia pulcherrima at dose 400 mg kg1 led to a dose dependent fall in blood sugar levels from 290-233 mg dL1 in 21 days (Group 6). Conclusion: Extracts of pods of C. pulcherrima are capable of exhibiting reduction in blood glucose level in normal and alloxan monohydrate-induced diabetic rats.
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