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Articles by Terdthai Tong-Un
Total Records ( 3 ) for Terdthai Tong-Un
  Terdthai Tong-un , Supaporn Muchimapura , Jintanaporn Wattanathorn and Wathita Phachonpai
  Problem statement: At present, the development of protective strategy against Alzheimer’s Disease (AD) is increasing its importance due to the high prevalence of AD, a limitation of therapeutic efficacy and its high impacts on economic and social aspects. The development of the preventive and therapeutic strategy to protect against the path physiology induced by free radicals in AD from antioxidant has gained very much concentration. Quercetin, one of the flavonoids in fruits and vegetables, has a powerful antioxidant activity both in vitro and in vivo. However, poor absorption, rapid metabolism and limited ability to cross the blood-brain-barrier are obstacles to its use for treatment of AD. Liposome’s have been used as an effective delivery system to the brain. Advantages associated with the nasal administration over oral route include higher bioavailability due to no first pass hepatic metabolism and rapid absorption leading to shorter time to onset of effect. Based on all these points, the possible effects of quercetin liposomes via nasal route on improving cognitive behavior and neurodegeneration in animal model of Alzheimer’s disease were investigated. Approach: Male Wistar rats were pretreated with quercetin liposome’s, containing 0.5 mg of quercetin in 20 μL (dose = 20 μg), via intranasal route once daily continually for 2 weeks before and 1 week after AF64A administration. Learning and memory was evaluated using the Morris water maze test at 7 days after the AF64A administration and then the rats were sacrificed for determining the density of neurons and cholinergic neurons in hippocampus using histological and immunohistochemical techniques. Results: Nasal administration of quercetin liposome’s significantly prevented changes of spatial memory of AF64A treated rats. The cognitive enhancement of quercetin liposome’s was found to be related to its ability to inhibit the degeneration of neurons and cholinergic neurons in hippocampus. Conclusion: Nasal administration of quercetin liposome’s possessed cognitive enhancer and neuroprotectant in animal model of AD, suggesting a potential novel therapeutic strategy against AD of quercetin liposomes.
  Terdthai Tong-un , Supaporn Muchimapura , Wathita Phachonpai and Jintanaporn Wattanathorn
  Problem statement: Demand for cognitive-enhancing drugs is growing. Numerous medicinal plants possessing antioxidant activity have received much attention as food supplement to improve cognitive function. Quercetin is a potent free radical scavenger and antioxidant. However, the limitations of quercetin: Rapidly metabolized is an obstacle to its use for a cognitive enhancer. In addition, the burden of blood brain barrier can be overcome by nasal administration and liposomes. In the present study, we investigated whether nasal administration of quercetin liposomes could improve spatial memory in healthy adult rats. Approach: Male Wistar rats were pretreated with quercetin liposomes, containing 0.5 mg of quercetin in 20 μL (dose = 20 μg), via right nasal cavity once daily continually for 4 weeks. Evaluation of rodent learning and memory was assessed by Morris water maze test and then all rats were sacrificed for determining the survival and cholinergic neurons densities in hippocampus. Results: Quercetin liposomes via nasal route treated rats exhibited a significant improvement in cognitive performance. In addition, nasal administration of quercetin liposomes also resulted in induced the densities of survival and cholinergic neurons in hippocampus. However, further researches about the precise underlying mechanism are still required. Conclusion: Our studies demonstrate that quercetin liposomes via nasal administration may have a candidate for cognitive enhancer in the future.
  Terdthai Tong-Un , Panakaporn Wannanon , Jintanaporn Wattanathorn and Wathita Phachonpai
  Problem statement: At present, the prevalence of neuropsychological disorders particularly anxiety, depression and dementia are increase. Many strategies have been developed in order to increase the efficiency of treatment and decrease side effects. Oxidative stress has been reported to play an important role on various path physiological states. Quercetin is a flavonoid commonly found in fruits and vegetables. It has potent antioxidant effects in vivo and in vitro. However, poor absorption, rapid metabolism and limited ability to cross the blood-brain-barrier are obstacles to its use for treatment of neuropsychological disorders. Nasal administration has been proposed as a non-invasive method to deliver bioactive substances to the brain. This route of administration has the potential of decreased hepatic metabolism and greater access to the brain tissue through the olfactory nerve compared to the oral route and could be a potential method of delivering quercetin to the CNS. Approach: This study was set up to determine the effect of quercetin liposomes via nasal administration on the anti-anxiety, anti-depression like activity and cognitive enhancing effect. In this case, Male Wistar rats were administered quercetin liposomes, containing 0.5 mg of quercetin in 20 μL (dose = 20 μg), via intranasal route once daily continually for 4 weeks. The anxiolytic activity, anti-depression like activity and cognitive enhancing effect were determined after single administration, 1-4 week of treatment using elevated plus maze test, forced swimming test and Morris water maze test respectively. Results: Quercetin liposomal encapsulation via nasal route possessed anxiolytic, anti-depression like activity and cognitive enhancing effect at all treatment duration. Conclusion: Our results demonstrated the anxiolytic, anti-depression like-activity and cognitive enhancing effect of quercetin liposomes via nasal administration and suggested that it might be used as a novel therapeutic strategy for mood disorder and cognitive deficit condition. However, further investigations about precise underlying mechanism are still required.
 
 
 
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