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Articles by Telesphore Benoit Nguelefack
Total Records ( 2 ) for Telesphore Benoit Nguelefack
  Sylvie Lea Wansi , Serges Kamdem Djoko , Albert Donatien Atsamo , Rodrigue Akoue Ngape , Elvine Pami Nguelefack-Mbuyo , Christian Fofie , Hubert Donfack , Telesphore Benoit Nguelefack and Albert Kamanyi
  Background: Commelina diffusa (C. diffusa) is a plant, traditionally used in Africa and Asia to treat hypertension, pain and renal diseases. The aim of the present study was to evaluate the diuretic potential and toxicological profile of the aqueous extract from the aerial part of Commelina diffusa (AECD). Materials and Methods: The aqueous extract was prepared by decoction of the powder obtained from the aerial part of C. diffusa and administered orally at the doses 100 and 200 mg kg-1 b.wt. for the study of diuretic activity in male rats. For the acute toxicity study 1.5, 3, 6 and 12 g kg-1 b.wt. were used, while 150, 300 and 600 mg kg-1 b.wt. were used for the sub chronic toxicity study in mice for 4 weeks. Furosemide, the reference drug (20 mg kg-1), was used as the positive control during the experiment. Blood sample collected was used to evaluate the concentrations of total proteins, creatinin and liver transaminases: Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST), while the urine sample collected was used to evaluate Na+, K+ and creatinin concentrations. Results: After acute and 7 day subchronic diuretic study, AECD at all doses and furosemide produced important and significant increments in urinary excretion of water and sodium in rats with respect to control group. AECD also induced K+ excretion increased but it was no significant and less than the one induced by furosemide. During the toxicity study, period, AECD may be devoided of acute toxicity and any other adverse effects, however, subchronic toxicity study revealed a significant increase in water consumption, ALT concentration and total proteins in serum. Conclusion: The strong diuretic, natriuretic properties and its K+ sparing effect make the AECD to be regarded as a good diuretic confirming their ethno pharmacological use. Also, AECD was found to be practically nontoxic.
  Romuald Tematio Fouedjou , Elvine Pami Nguelefack-Mbuyo , Beaudelaire Kemvoufo Ponou , Telesphore Benoit Nguelefack , Luciano Barboni and Leon Azefack Tapondjou
  Background and Objective: Cordyline fruticosa (Agavaceae) and Eriobotrya japonica (Rosaceae) are two medicinal plants used for the treatment of various diseases such as infections of mammary glands, sore throat and neck pain for the first plant, diabetes, cough, ulcers, protection against oxidative stress and cognitive deficits for the latter. The present study was designed to evaluate the antioxidant activity of the different extracts of these two plants as well as to isolate and identify their chemical constituents. Materials and Methods: The plant extract was prepared by maceration in methanol, compounds were isolated from EtOAc and n-BuOH extracts of the two plants using column chromatography and their structures were determined by means of NMR and MS analysis as well as in comparison with published data. Antioxidant tests (DPPH, ferric reduction antioxidant power and anti-hemolytic) were performed over the MeOH, EtOAc and n-BuOH extracts of the plants. Results: The antioxidant-guided phytochemical investigation of the MeOH extracts of the two plants led to the isolation of twelve compounds identified as: Farrerol 1, quercetin helichrysoside 2, apigenin 8-C-β-D-glucopyranoside 3, isoquercitrin 4 and rutin 5 from C. fruticosa, β-sitosterol 6, catechin 7, oleanolic acid 8, lyoniresinol 9, cinchonain IIb 10, lyoniresinol 2-a-O-β-D-xylopyranoside 11 and β-sitosterol-3-O-β-D-glucopyranoside 12 from E. japonica. Amongst the isolated compounds, the most important antioxidant ones were identified as helichrysoside and rutin from C. fruticosa, catechin, cinchonain IIb, lyoniresinol 2-a-O-β-D-xylopyranoside from E. japonica with EC50 of 8.73, 9.91, 4.11, 3.14 and 10.61 μg mL–1, respectively. Conclusion: Based on the obtained results, it can be concluded that the high ability to scavenge free radicals, reducing power of Fe3+ and hemolysis activity exerted by extracts of C. fruticosa and E. japonica were due to their high content of phenolic compounds, thus the structure-activity relationships of the isolated flavonoids were discussed. The results of this study suggest that the extracts from these two plants could serve as potential source of antioxidant compounds.
 
 
 
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