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Articles by Tarek El-Nimr
Total Records ( 1 ) for Tarek El-Nimr
  Afrah Salama , Wafaa Ibrahim , Tarek El-Nimr , Mahmoud A. Abd El-Rahman and Ehab Tousson
  Background: Diabetes is a metabolic disorder characterized by resistance to the action of insulin, insufficient insulin secretion or both. The major clinical manifestation of the diabetic state is hyperglycemia. However, insulin deficiency and/or insulin resistance also are associated with disturbances in lipid and protein metabolism. Myrrh (from the stem of the Commiphora molmol tree) is an oleo gum resin that may prove efficacious for the treatment of fascioliasis. The effect of myrrh on diabetes treatment is still unknown, therefore this study aimed to showing the effect of myrrh extract on diabetic rats. Materials and Methods: A total of 100 Albino rats were equally divided to 5 groups [control (G1), diabetic (G2), mirazid (G3), co-treated diabetic rats with amaryl (G4) and co-treated diabetic rats with mirazid (G5)]. Induction of Type II DM was carried out by intraperitoneal injection of 65 mg kg-1 b.wt. of streptozotocin. Many biochemical and physiological parameters were determined as changes in body weight gain percent, oral glucose tolerance test, insulin, insulin sensitivity percent, Liver glycogen content, fructosamine, liver and kidney functions. Also, total protein and total antioxidant capacity in serum, liver and in kidney homogenate in different groups under study were detected. Results: Myrrh extracts have hypoglycemic activity through decreasing blood glucose level, enhancing insulin secretion, increasing liver glycogen content and decreasing serum fructosamine. Myrrh extracts have antioxidant activity through increasing total antioxidant activity of serum and tissues, increasing total protein in tissues and enhancing liver enzyme AST and kidney function. Conclusion: This study concluded that Myrrh extracts have hypoglycemic activity and antioxidant activity through decreasing total antioxidant activity.
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