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Articles by Tarek M. Heikal
Total Records ( 2 ) for Tarek M. Heikal
  Abdel-Tawab H. Mossa , Tarek M. Heikal , Samia M.M. Mohafrash and Amel A. Refaie
  The present experiment was designed to evaluate the oxidative damage and hepatotoxicity resulting from Pirimiphos-Methyl (PM) exposure as well as the hepatoprotective potential of Origanum majorana L. leaves extract in male mice. The results revealed that Majorana leaves extract exhibited antioxidant capacity manifested by inhibitory effects on DPPH, ABTS, hydroxyl radical and reducing power in vitro. Male mice were divided into six groups of six mice each: Control group (I) extract groups (II and III) received an extract at doses of 150 and 300 mg kg-1 b.wt.; PM group (IV) received PM (12.0 mg kg-1 b.wt., 1/10 LD50) in corn oil; groups (V and VI) received PM along with the two doses of extracts. All the applications were administered via oral route for 28 consecutive days. Exposure of mice to PM caused significant changes in body and relative liver weights as well as significant increases in the activity of serum enzymes alanine aminotransferases (ALT), aspartate aminotransferases (AST), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH). Also, PM induced significant decreases in the activities of hepatic superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and in the content of glutathione reduced (GSH), however, induced a significant increase in the level of hepatic lipid peroxidation (LPO) accompanied by histopathological alterations in liver of male mice. Co-administration of O. majorana extract to PM ameliorated the above-mentioned parameters. The ultimate effect was achieved by the highest dose of the extract. It could be concluded that PM induced oxidative damage and liver injury in male mice. However, co-administration of O. majorana leaves extract attenuated the harmful effects of PM which may be attributed to its antioxidant potential. Results indicated that O. majorana leaves could be used for therapeutic option against hepatic injuries resulting from pesticide intoxication.
  Tarek M. Heikal , Abdel-Tawab H. Mossa , Azza W. Ibrahim and Hala F. Abdel-Hamid
  Pesticides have contributed for many public health hazards in man including infertility. So, the present study aimed to assess the protective role of green tea extract (GT) against the possibility of reproductive toxicity resulting from chlorpyrifos (CPF), cyromazine (Cyr) and their combination exposure in mature male Wistar rats. Rats were administered CPF (5.4 mg kg-1 b.wt., 1/25 LD50), Cyr (135.48 mg kg-1 b.wt., 1/25 LD50), CPF+Cyr, GT (1.5% w/v in water) as the only drinking fluid, CPF+GT, Cyr+GT and CPF+Cyr+GT daily via gavage for 70 days to complete the spermatogenic cycle. The results revealed that exposure to CPF, Cyr and CPF+Cyr significantly decreased the fertility index, weights of sexual organs (testes, seminal vesicles, epidermis and prostate gland), sperm characteristics (motility and count) as well as serum testosterone level, while increased sperm abnormality. In addition, the testicular tissue level of reduced glutathione (GSH) and the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione-S-transferase (GST) enzymes were significantly decreased while increased the level of testicular tissue lipid peroxidation (LPO) compared with the control group. The testicular histopathological lesions were characterized by moderate to severe degenerative changes of seminiferous tubules and incomplete arrest of spermatogenesis. Co-administration of GT to treated-animals alleviates the reproductive toxicity and testicular oxidative damage. In conclusion, the use of green tea extract appeared to be beneficial in attenuating and improving the testicular damage and reproductive toxicity sustained by insecticide exposure in male rats.
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