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Articles by Tao Wang
Total Records ( 12 ) for Tao Wang
  Jing Gu , Joseph T.F. Lau , Hongyao Chen , Zhiming Liu , Zhangquan Lei , Zhenglin Li , Zhi Lian , Renfan Wang , Xianyou Hu , Hua Cai and Tao Wang
  No fully validated Chinese instrument measuring severity of drug dependence exists. The Chinese Opiate Addiction Severity Inventory (OASI) and the translated Chinese version of the Severity of Dependence Scale (SDS) were validated in this study. A total of 178 eligible participants were recruited using snowballing method. The 11-item revised version of OASI (OASI-R) exhibited good reliability (item-total correlation coefficients ranged from 0.50 to 0.73, Cronbach’s alpha was 0.85, test–retest Intra-class Correlation Coefficient was 0.81, p < 0.001). Two factors were identified by principal component method and correlated significantly with the Quality of Life-Drug Addiction (QOL-DA). The 3-item revised version of SDS (SDS-R) was one of the two factors of SDS (item-total correlation coefficients were 0.79 to 0.86, ’s alpha was 0.78, test–retest Intra-class Correlation Coefficient was 0.64, < 0.001). It correlated significantly with QOL-DA. OASI-R and SDS-R were also significantly correlated with each other and with some heroin-related characteristics. The validation of the Chinese version of OASI-R and SDS-R would facilitate research in different Chinese populations. SDS has been translated to different languages and the Chinese version allows for international comparison.
  Guangzheng Li and Tao Wang
  Grey theory is one of the research methods of uncertainty, which is superior in the mathematical analysis of systems with uncertain information. This study develops a data processing method with grey theory toward data fusion for ship navigation and collision avoidance system. In view of the information complementarities between Automatic Radar Plotting Aid (ARPA) radar and Automatic Identification System (AIS), we fuse AIS information with ARPA radar and present an information fusion framework based on gray theory to provide more accurate and reliable data for ship navigation and collision avoidance system. Owning to the lack of track association based on fuzzy mathematics and statistics, we propose a novel track association algorithm based on grey theory. The simulation results demonstrate that the identification accuracy is 98-99% in the circumstance of about 40 target ships. It has a high matching rate of track association.
  Lianqing Fu , Shizhong Yang , Tao Wang and Yaning Ma
  In this study, the important function of netted radar system is discussed and its serious problem that mutual interference between transmitted signals, when it works in practice. In order to reduce the influence of mutual interference between signals, a novel netted radar system is designed. Transmitted signal of each station is assigned a unique Pseudo Noise (PN) code and all the PN codes from different stations are orthogonal. Because of the good autocorrelation and cross-correlation properties, mutual interference becomes weaker and signals from different stations could be separated by the preassigned PN codes and several radar stations can be active simultaneously. At the same time, the spectrum of the emission signal is spreaded, the Peak-to-mean Envelope Power Ratio (PMEPR) and the intercepted probability of the signals descend therefore. Simulation results show the good performance of the proposed approach and real radar system's detect result confirms the proposal.
  Ping-Er Lou , Ying-Kai Liu , Tao Wang , Ming-Zhou Li and Xue-Wei Li
  Monozygotic (MZ) twins having the same DNA information have been used for many biomedical studies. Pigs present high similarity with humans and have been used as an ideal mammalian model the use of MZ twins is even more valuable. In the study, researchers present a systematic method for the stepwise exclusion of inconsistently genotyped individuals in a large population by Short Tandem Repeat (STR) genotyping. Five pairs of microsatellite markers with different fluorescent dyes were selected and their reliability was tested. The results demonstrate that the cumulative exclusion rate of all markers was 99.67% in 1,201 pigs; two pairs of MZ twins were initially identified. Researchers have established an effective, easy and cheap way to identify MZ twin pigs.
  Jun Chen , Jihong Liu , Tao Wang , Hengjun Xiao , Chunping Yin , Jun Yang , Xiaowen Chen and Zhangqun Ye
  The relaxation mechanisms of tetrandrine (Tet) on the rabbit corpus cavernosum tissue in vitro were investigated. Strips of rabbit corpus cavernosum were mounted in organ chambers. The effects of Tet were examined on isolated muscle strips pre-contracted with phenylephrine (PE) alone, in the presence of NW-nitro-L-arginine (LNNA, a nitric oxide synthase inhibitor), 1-H-[1,2,4]oxadiazolo[4,3-α]quinoxalin-1-one(ODQ, a guanylyl cyclase inhibitor), indomethacin (cyclooxygenase inhibitor), tetraethylammonium (TEA, Ca2+-activated K+ channel blocker), 4-aminopiridine (4-AP, voltage dependent K+ channel blocker) and glibenclamide (ATP sensitive K+channel blocker). The effects of Tet on KCl-induced contraction of isolated muscle strips were also investigated. The procedure of calcium absence-calcium addition was designed to observe the effect of Tet on the two components of the contractile responses to PE based on the source of Ca2+ (extracellular vs. intracellular). Corpus cavernosum strips showed relaxation in response to Tet (10-8 ~ 10-3 mol L-1) in a concentration-dependent manner with an IC50 of 3.73 x 10-5 mol L-1. However, they were not affected by LNNA, ODQ, indomethacin and K+-channel blockers. Tet (10 μmol L-1, 30 μmol L-1) concentration dependently reduced the maximal contraction response of isolated strips induced by KCl to (73.0 ± 3.8) and (41.5 ± 3.4)%, respectively (p < 0.01). In the procedure of calcium absence-calcium addition, Tet 100 μmol L-1 inhibited both intracellular calcium-dependent and extracellular calcium-dependent contraction induced by PE (20 μmol L-1) (p < 0.05). The inhibition ratios were (23.8 ± 7.1) and (40.7 ± 11.2)%, respectively. The results of the present study suggest that Tet possesses a relaxant effect on rabbit corpus cavernosum tissues, which is attributable to the inhibition of extracellular Ca2+ influx and the inhibition of release of intracellular-stored Ca2+, but not mediated by the release of nitric oxide, prostaglandins or by the activation of potassium channels.
  Tao Wang , Jixiong Pu and Ziyang Chen
  We theoretically and experimentally investigate the beam-spreading of a vortex beam propagating in a turbulent atmosphere. It is found that the vortex beam is less affected by turbulence than a non-vortex one. The topological charge of the vortex beam on propagation has also been investigated experimentally. It is shown that the topological charge of vortex beam will exhibit fluctuating behavior as the beam propagates through a turbulent atmosphere.
  Bo ZHU , Tao WANG , Xiang YOU and Mei-Rong GAO
  Purplish soils having high fertility with mineral nutrients inherited from the parent rock are widely distributed in the hills along the Yangtze River, especially in the Sichuan Basin. Pot and field weathering experiments were conducted to mimic rock weathering and nutrient release processes in order to better understand soil fertility and nutrient compensation. Three types of purplish rock formations formed in the Jurassic period, Shaximiao (J2s), Suining (J3s), and Penglaizhen (J3p), as well as one type formed in the Cretaceous period, the Chengqiangyan group (K1c), were used in this study. Results showed that the soil formation rate was in the range from 11.2 to 19.6 mm every year, and rock weathering was in the order of J3s > J3p > J2s > K1c. Because more rock surface was exposed to sunlight and rainfall in field conditions, pot weathering was slower than field weathering. Nutrient release rates increased with rock weathering and was in the order similar to that of rock weathering: J3p > J3s > J2s > K1c. Potassium release was the most important in all rocks; after 2 years of weathering, 19.4% to 46.9% of K was released from the initial parent rocks, which suggested that K release from weathering could meet most of the crop K requirement in purplish soils. Thus, rapid release of nutrients from weathering of purplish rocks was key to nutrient replenishment and fertility of purplish soils.
  Tao Wang and Elizabeth A. Craig
  Friedreich ataxia is caused by reduced activity of frataxin, a conserved iron-binding protein of the mitochondrial matrix, thought to supply iron for formation of Fe-S clusters on the scaffold protein Isu. Frataxin binds Isu in an iron-dependent manner in vitro. However, the biological relevance of this interaction and whether in vivo the interaction between frataxin and Isu is mediated by adaptor proteins is a matter of debate. Here, we report that alterations of conserved, surface-exposed residues of yeast frataxin, which have deleterious effects on cell growth, impair Fe-S cluster biogenesis and interaction with Isu while altering neither iron binding nor oligomerization. Our results support the idea that the surface of the β-sheet, adjacent to the acidic, iron binding ridge, is important for interaction of Yfh1 with the Fe-S cluster scaffold and point to a critical role for frataxin in Fe-S cluster biogenesis.
  Joseph M. Gozgit , Geraldine Bebernitz , Pankaj Patil , Minwei Ye , Julie Parmentier , Jiaquan Wu , Nancy Su , Tao Wang , Stephanos Ioannidis , Audrey Davies , Dennis Huszar and Michael Zinda
  The Janus-associated kinase 2 (JAK2) V617F mutation is believed to play a critical role in the pathogenesis of polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis. We have characterized a novel small molecule JAK2 inhibitor, AZ960, and used it as a tool to investigate the consequences of JAK2 V617F inhibition in the SET-2 cell line. AZ960 inhibits JAK2 kinase with a Ki of 0.00045 µM in vitro and treatment of TEL-JAK2 driven Ba/F3 cells with AZ960 blocked STAT5 phosphorylation and potently inhibited cell proliferation (GI50 = 0.025 µM). AZ960 demonstrated selectivity for TEL-JAK2-driven STAT5 phosphorylation and cell proliferation when compared with cell lines driven by similar fusions of the other JAK kinase family members. In the SET-2 human megakaryoblastic cell line, heterozygous for the JAK2 V617F allele, inhibition of JAK2 resulted in decreased STAT3/5 phosphorylation and inhibition of cell proliferation (GI50 = 0.033 µM) predominately through the induction of mitochondrial-mediated apoptosis. We provide evidence that JAK2 inhibition induces apoptosis by direct and indirect regulation of the anti-apoptotic protein BCL-xL. Inhibition of JAK2 blocked BCL-XL mRNA expression resulting in a reduction of BCL-xL protein levels. Additionally, inhibition of JAK2 resulted in decreased PIM1 and PIM2 mRNA expression. Decreased PIM1 mRNA corresponded with a decrease in Pim1 protein levels and inhibition of BAD phosphorylation at Ser112. Finally, small interfering RNA-mediated suppression of BCL-xL resulted in apoptotic cell death similar to the phenotype observed following JAK2 inhibition. These results suggest a model in which JAK2 promotes cell survival by signaling through the Pim/BAD/BCL-xL pathway.
  Dajiang Qin , Yi Gan , Kaifeng Shao , Hao Wang , Wen Li , Tao Wang , Wenzhi He , Jianyong Xu , Yu Zhang , Zhaohui Kou , Lingwen Zeng , Guoqing Sheng , Miguel A. Esteban , Shaorong Gao and Duanqing Pei
  Induced pluripotent stem cell technology, also termed iPS, is an emerging approach to reprogram cells into an embryonic stem cell-like state by viral transduction with defined combinations of factors. iPS cells share most characteristics of embryonic stem cells, counting pluripotency and self-renewal, and have so far been obtained from mouse and humans, including patients with genetic diseases. Remarkably, autologous transplantation of cell lineages derived from iPS cells will eliminate the possibility of immunological rejection, as well as current ethical issues surrounding human embryonic stem cell research. However, before iPS can be used for clinical purposes, technical problems must be overcome. Among other considerations, full and homogeneous iPS reprogramming is an important prerequisite. However, despite the fact that cells from several mouse tissues can be successfully induced to iPS, the overall efficiency of chimera formation of these clones remains low even if selection for Oct4 or Nanog expression is applied. In this report, we demonstrate that cells from the mouse meningeal membranes express elevated levels of the embryonic master regulator Sox2 and are highly amenable to iPS. Meningeal iPS clones, generated without selection, are fully and homogeneously reprogrammed based on DNA methylation analysis and 100% chimera competent. Our results define a population of somatic cells that are ready to undergo iPS, thus highlighting a very attractive cell type for iPS research and application.
  Xiaofei Zhang , Juan Zhang , Tao Wang , Miguel A. Esteban and Duanqing Pei
  The genetic program of embryonic stem (ES) cells is orchestrated by a core of transcription factors that has OCT4, SOX2, and NANOG as master regulators. Protein levels of these core factors are tightly controlled by autoregulatory and feed-forward transcriptional mechanisms in order to prevent early differentiation. Recent studies have shown that knockdown of Esrrb (estrogen-related-receptor β), a member of the nuclear orphan receptor family, induces differentiation of mouse ES cells cultured in the presence of leukemia inhibitory factor. It was however not known how knocking down Esrrb exerts this effect. Herein we have identified two ESRRB binding sites in the proximal 5'-untranslated region of the mouse Oct4 gene, one of which is in close proximity to a NANOG binding site. Both ESRRB and NANOG are necessary for maintaining the activity of this promoter in ES cell lines. We have also demonstrated that the two transcription factors interact through their DNA binding domains. This interaction reciprocally modulates their transcriptional activities and may be important to fine-tune ES cell pluripotency. Supporting all of these data, stable transfection of Esrrb in ES cell lines proved sufficient to sustain their characteristics in the absence of leukemia-inhibitory factor. In summary, our experiments help to understand how Esrrb coordinates with Nanog and Oct4 to activate the internal machinery of ES cells.
  Yankun Li , Yuan Zhang , Bernhard Dorweiler , Dongying Cui , Tao Wang , Connie W. Woo , Cynthia S. Brunkan , Cynthia Wolberger , Shin-ichiro Imai and Ira Tabas
  Macrophages play key roles in obesity-associated pathophysiology, including inflammation, atherosclerosis, and cancer, and processes that affect the survival-death balance of macrophages may have an important impact on obesity-related diseases. Adipocytes and other cells secrete a protein called extracellular nicotinamide phosphoribosyltransferase (eNampt; also known as pre-B cell colony enhancing factor or visfatin), and plasma levels of eNampt increase in obesity. Herein we tested the hypothesis that eNampt could promote cell survival in macrophages subjected to endoplasmic reticulum (ER) stress, a process associated with obesity and obesity-associated diseases. We show that eNampt potently blocks macrophage apoptosis induced by a number of ER stressors. The mechanism involves a two-step sequential process: rapid induction of interleukin 6 (IL-6) secretion, followed by IL-6-mediated autocrine/paracrine activation of the prosurvival signal transducer STAT3. The ability of eNampt to trigger this IL-6/STAT3 cell survival pathway did not depend on the presence of the Nampt enzymatic substrate nicotinamide in the medium, could not be mimicked by the Nampt enzymatic product nicotinamide mononucleotide (NMN), was not blocked by the Nampt enzyme inhibitor FK866, and showed no correlation with enzyme activity in a series of site-directed mutant Nampt proteins. Thus, eNampt protects macrophages from ER stress-induced apoptosis by activating an IL-6/STAT3 signaling pathway via a nonenzymatic mechanism. These data suggest a novel action and mechanism of eNampt that could affect the balance of macrophage survival and death in the setting of obesity, which in turn could play important roles in obesity-associated diseases.
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