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Articles by Tabassum Mahboob
Total Records ( 5 ) for Tabassum Mahboob
  Syed Muhammad Shahid and Tabassum Mahboob
  It is recently established that serum sialic acid is a potent cardiovascular and renal risk factor in general population and also found elevated in diabetic type 2 patients. This study was designed to assess the coexistence of frequently documented risk factors of diabetic nephropathy with serum sialic acid. A total of 100 diabetic patients (50 with and 50 without nephropathy) aged 47.56±10.68 (mean±SD) year attending several diabetic clinics of private sector in Karachi were included after informed consent was obtained. Systolic and diastolic blood pressures were recorded by standard mercury sphygmomanometer. Fasting blood samples were collected for the estimations of blood glucose, HbA1c, serum urea, creatinine and sialic acid levels. Serum sialic acid, glucose, HbA1c, urea and creatinine levels were increased significantly (p<0.01) in diabetic nephropathy patients as compared to diabetic patients without nephropathy. Regression and correlation analysis showed a significant positive correlation between serum sialic acid and fasting blood glucose, HbA1c, serum urea and creatinine levels. BMI and blood pressures were also significantly high in diabetic patients with nephropathy as compared to those without nephropathy. Fifty four percent diabetic nephropathy patients were found to be smokers where as 41% were smokers in diabetic patients without nephropathy. It is concluded that the elevated serum sialic acid level is strongly associated with the presence of microvascular complications of diabetes, nephropathy for example. There is a significant unvaried link between serum sialic acid and diabetic nephropathy. The consideration of sialic acid as potent disease marker for diabetic nephropathy is therefore justified.
  Hina Akram and Tabassum Mahboob
  Oxidative damage induced by free globin chains has been implicated in the pathogenesis of the membrane abnormalities observed in β thalassemia. We determined whether thalassemia could account for abnormal cation transport system. During a study of clinical and laboratory features in 70 patients with thalassemia (age between 2-20 years) along with same number of healthy teenagers, we have evaluated erythrocyte Na, K content, membrane bound Na-K-ATPase activity and PCV (packed cell volume). Serum levels of Na, K, Mg+2, Ca+2 and Li were also measured. With the exception of K, altered levels of cation were observed. We found significant decrease in the PCV values. Red cell Na-K-ATPase activity also reduced significantly, where as red cell Na was significantly increased. We also observed a significant reduction in the concentrations of serum Ca+2, Mg+2 and Li. Serum Na was increased significantly. We can conclude that defective membranal transport is responsible for observed changes of electrolytes in red cell and serum. These results may help to understand the altered electrolyte homeostasis in thalassemia but there is still need of many future studies to clarify their mechanism of generation and pathological significance.
  Shafaq Noori , Nayab Rehman , Madiha Qureshi and Tabassum Mahboob
  Cirrhosis is one of the most degenerative, world wide diseases and can be lead to an inability of liver functions. Green Tea (GT) and Coffee are natural products and considered as powerful antioxidant, chemoprotective, antiinflammatory and antitumorigenic agent. The present study was designed to investigate the protective effect of green tea and coffee against Carbon tetrachloride (CCl4)-induced liver cirrhosis by using biochemical and histopathological parameters. 24 Male Albino Wistar rats were randomly divided into 6 groups; each group consists of 4 rats. Group I comprises normal healthy rats remains untreated; Group II comprises of CCl4 (0.8 mg/kg) induced Cirrhotic rats; Group III was administered coffee orally (1 gm/100 mL) daily; Group IV administered CCl4 (0.8 mg/kg) intraperitoneally once a week for 8 weeks+ 1% oral administration of coffee; Group V was administered 5% Green tea orally; Group VI comprises of CCl4 (0.8 mg/kg) intraperitoneally once a week for 8 weeks+ 5% oral administration of Green Tea. The volume of green tea and coffee ingested by rats of group III and V was measured daily. The effect of antioxidants on CCl4-induced liver cirrhosis were estimated by plasma ALT, ALP, total and direct bilirubin, tissue MDA, tissue SOD, tissue catalase. CCl4-induced cirrhosis is indicated by increased level of plasma ALT, direct bilirubin, tissue MDA and decreased level of tissue SOD. Pathological changes induced by CCl4 were characterized by fibrotic scar tissue as well as regenerative nodules, the parenchyma deteriorates; the lobules are infiltrated with fat and structurally altered; dense perilobular connective tissue. Coffee and green tea reduced these changes and also restored antioxidant and liver enzymes. Our results showed the possible protective effect of coffee and green tea in association with liver and antioxidant enzymes, indicated that administration of coffee and green tea not only reversed the pathological effects of CCl4 but also counteracted on deleterious effects of CCl4- induced liver injury.
  Shafaq Noori , Humaira Zafar and Tabassum Mahboob
  Cocoa beans are main ingredient of chocolate, cakes, cookies and coffee. Cocoa have health benefits effects, previously reported. This study was designed to evaluate the health effects of cocoa powder on different biochemical parameters. For this purpose 12 Male Albino Wistar rats were divided in to 2 groups (n = 6). Group I remain healthy control rats; Group II received cocoa powder at a dose of (1 g/kg b.w.) for 21 consecutive days orally. Biochemical analysis was evaluated by electrolytes homeostasis, liver specific enzymes, kidney markers and LDH cardiac specific enzyme. The cocoa-treated rats showed decreased intra-erythrocytes potassium, increased Na+-K+-ATPase, decreased direct bilirubin, increased plasma potassium, increased ALT level. Decreased mean body weight was observed. No mortality and sign of toxicity was observed at this dose. Considerable changes were observed in biochemical parameters after chronic administration of cocoa powder.
  Nazish Iqbal Khan and Tabassum Mahboob
  Present study is designed to investigate the atheroprotective potential of curcumin in rat models of diet induced dyslipidemia. Twenty four wistar rats of same age and sex were selected for the study and divided into four experimental groups with six animals per group. Group I was control untreated rats, group II rats received high fat diet for eight weeks, group III received 0.2 g/kg of body weight/day curcumin together with fat diet and group IV had only curcumin administration for upto four weeks. Results showed that curcumin treatment with or without fat diet administration significantly reduce plasma lipid levels, ALT, AST, ALP and glucose concentrations. High fat diet administration significantly suppresses levels of catalase, SOD and glutathione in these tissues. Whereas MDA levels were significantly raised. Curcumin treatment improve these tissue antioxidant enzyme status together with decreased MDA levels. These results suggests that daily dietary intake of curcumin in recommended doses may be helpful in restoring lipid disorders and maintaining body’s antioxidant status in patients of cardiovascular diseases.
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