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Articles by Tabassum Mahboob
Total Records ( 2 ) for Tabassum Mahboob
  Najma Shaheen , Syed Muhammad Shahid and Tabassum Mahboob
  Calcium concentration plays an important role in the development of diabetic complications in tissues permeable to glucose like liver, blood vessels of retina, kidney and central and peripheral nervous systems. This study was designed to investigate the possible involvement of intracellular electrolytes in antihypertensive effects of diltiazem in diabetes. In diltiazem treated control rats serum, heart, kidney calcium and magnesium were significantly decreased where as RBC, heart potassium and magnesium and Na-K-ATPase activity were significantly increased as compared to control animals. In STZ-induced diabetic rats serum sodium, magnesium, RBC potassium, ATPase activity, heart and kidney potassium were significantly decreased while serum potassium, glucose, RBC and heart sodium were significantly increased. In diltiazem treated diabetic rats serum and heart magnesium and serum glucose were increased where as RBC, heart, kidney sodium, heart, kidney calcium, kidney magnesium and kidney potassium were decreased significantly as compared to control rats. It is assumed that total peripheral resistance, systemic blood pressure and after load is decreased and thus diltiazem is useful in managing angina and hypertension in diabetes by decreasing calcium and sodium in heart and kidney tissues. Diltiazem may be useful in improving the clinical benefits for cardiovascular complications in diabetes.
  Syed Muhammad Shahid and Tabassum Mahboob
  Diabetes mellitus and hypertension frequently coexist. A variety of aberrations have been reported in the metabolism of body chief electrolytes (such as Na+, K+, Ca++ and Mg++) and their transport systems in intra and extracellular environment in various metabolic disorders. The study was aimed to examine the similar abnormality in diabetes with hypertension. Thirty hypertensive diabetic patients were selected verses same number of age and sex matched controls with no known history of hyperglycemia and hypertension. A significant difference was observed in blood pressures of both the groups. Intra-erythrocyte sodium level was observed elevated significantly (P<0.01) where as intra-erythrocyte potassium was observed lower significantly (P<0.05) in hypertensive diabetic patients. The serum sodium, calcium, magnesium as well as membrane Na-K-ATPase activity were observed reduced to a significant level (P<0.01) where as serum potassium level was also found reduced significantly (P<0.05) in hypertensive diabetic patients as compare to controls. These findings suggest that the constellation of disturbed cellular ions and their transport mechanisms may critically contribute to pathophysiology of these syndromes and may help to explain their frequent clinical coexistence.
 
 
 
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