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Articles by Tabarak Malik
Total Records ( 1 ) for Tabarak Malik
  Tabarak Malik , Devendra Kumar Pandey and Nitu Dogra
  Paracetamol (also known as Acetaminophen) is a cheap but effective analgesic with few side-effects. However, outside of the therapeutic window, the liver’s ability to process the toxic metabolites of paracetamol is exceeded and hepatotoxicity may result in the process. The present study was undertaken exhaustively to investigate hepatoprotective activity of Withania somnifera root extract against paracetamol induced hepatotoxicity, in mice. Activities of liver markers enzymes Glutamate-oxaloacetate Transaminase (AST), Glutamate-pyruvate Transaminase (ALT), Alkaline Phosphatase (ALP), Bilirubin and total protein were estimated in serum, whereas, lipid peroxidation and antioxidant status (Superoxide dismutase, Catalase, Glutathione Peroxidase and Reduced glutathione content) were estimated in liver homogenate. Paracetamol (500 mg kg-1 b.wt.) induced hepatotoxicity was established by a significant increase in serum AST, ALT, ALP activity and bilirubin level accompanied by significant decrease in total serum protein level. Paracetamol hepatotoxicity was evident by an increase in lipid peroxidation, reduction of reduced glutathione content, Catalase, Glutathione reductase and Glutathione peroxidase activity in liver. Treatment of Withania somnifera root extract (500 mg kg-1 b.wt.) notably decreased AST, ALT, ALP, Bilirubin and Total Protein content in PCM compared to control. In addition Withania somnifera root extract significantly reduced hepatic lipid peroxidation, enhanced antioxidant enzyme activities and GSH levels in the liver of mice.
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