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Articles by T.S. Shanmugarajan
Total Records ( 4 ) for T.S. Shanmugarajan
  T.S. Shanmugarajan , M. Arunsundar , I. Somasundaram , E. Krishnakumar , D. Sivaraman and V. Ravichandiran
  The current communication was designed to assess the cardioprotective effect of the methanolic leaf extract of Ficus hispida Linn. (FH) (400 mg kg-1 body weight, administered orally for 10 days) on cyclophosphamide (CP) provoked oxidative injury in rat heart. CP cardiotoxicity, induced by single intraperitoneal injection (200 mg kg-1 b.wt.), was revealed by elevated serum creatine phosphokinase (CPK), lactate dehydrogenase (LDH), aspartate transaminase (AST) and alanine transaminase (ALT). CP induced rats, treated with FH depicted near normalcy in these parameters. In the CP group, increased oxidative stress was evidenced by a significant rise in myocardial malondialdehyde (MDA) level and decline in superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST) and reduced glutathione (GSH) activities in the heart tissue. FH treated rats displayed a significant inhibition of lipid peroxidation (LPO) and augmentation of endogenous antioxidants. These results give credence to the notion that treatment with F. hispida leaf extract ameliorates CP induced cardiotoxicity and might serve as a novel combination therapy with CP to combat oxidative stress-mediated myocardial injury.
  T.S. Shanmugarajan and T. Devaki
  The present study was set out to explore the antioxidant effect of methanolic leaf extract of Ficus hispida Linn. (FH) against azathioprine (AZA) induced liver injury in male Wistar rats. In vitro antioxidant activity of FH was examined by 1,1-diphenyl-2-picrylhydrazyl (DPPH) and nitric oxide radical inhibition assays, the extract exhibited IC50 values of 29.33 ±1.14 and 21.51 ±0.96 μg mL-1, respectively. The in vivo experiments revealed that AZA (50 mg kg-1 body weight; single intraperitoneal injection) caused a severe oxidative insult in the liver, which was depicted by a substantial drop in the enzymic [superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione-S-transferase (GST)] and non-enzymic antioxidants [glutathione (GSH), Vitamin C (Vit C), Vitamin E (Vit E)]. In contrary, pretreatment with FH (400 mg kg-1 body weight; pretreated orally for 21 days) maintained the antioxidant status at near normalcy. In addition, AZA induced lipid peroxidation (LPO) was also significantly alleviated by FH administration. These results underscore that Ficus hispida leaves possess remarkable antioxidant potential and hence it could be evaluated as an effective supplement to attenuate azathioprine induced oxidative stress.
  T.S. Shanmugarajan , M. Arunsundar , I. Somasundaram , D. Sivaraman , E. Krishnakumar and V. Ravichandran
  The current study was designed to scrutinize the putative hepatoprotective potential of the methanolic leaf extract of Ficus hispida Linn. (FH) (400 mg kg-1 body weight) on cyclophosphamide (CP) elicited oxidative injury in rat liver. CP administration (150 mg kg-1 body weight, i.p., twice, in 2 consecutive days) caused liver injury, featuring substantial increase in serum aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), gamma-glutamyl transpeptidase (GGT) and bilirubin levels. In contrast, treatment with FH significantly precluded all these alterations. CP intoxicated rats depicted a remarkable oxidative stress, as evidenced by a significant elevation in lipid peroxidation (LPO) with a concomitant decrease in the GSH activity. These changes were coupled with a marked decline in the activities of enzymic antioxidants [superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST) and glutathione reductase (GR)] in the liver tissue of CP-administered rats. FH treated rats displayed a significant inhibition of lipid peroxidation (LPO) and augmentation of endogenous antioxidants. Taken together, these findings emphasize the hepatoprotective effect of F. hispida leaf extract against CP-induced oxidative liver injury. Hence, F. hispida might serve as a promising medicinal herb in complementary chemotherapeutic modalities.
  T.S. Shanmugarajan , M. Niladri , I. Somasundaram , N. Prithwish , Soncharan Patel and K. F. H. Nazeer Ahamed
  Adjuvant arthritis is one of the extensively used models of chronic inflammatory joint disorder such as rheumatoid arthritis. It is postulated that oxidative stress plays a pivotal role in rheumatoid arthritis. The current research was designed to examine the antioxidative effect of Gaultheria fragrantissima Wall. (Ericaceae) against complete Freund’s adjuvant induced arthritis. Arthritis was induced by single subcutaneous injection of complete Freund’s adjuvant (0.1mL) into the plantar surface of the right hind paw of male Wistar rats. Gaultheria fragrantissima leaf extracts (100 and 200mg kg−1day−1) and indomethacin (3mg kg−1day−1) were administered orally for 14 days (from day 14 to day 28) after the adjuvant injection. The protective effect was evaluated by DPPH radical scavenging activity, alterations in paw volume, lipid peroxidation (measured in terms of MDA), antioxidant, enzymatic (SOD, CAT, GPx, GR and GST), nonenzymatic (GSH), and marker enzymes (AST, ALT, ALP and GGT) levels from liver and serum of adjuvant induced and treatment groups. These biochemical alterations were significantly (p<0.05) ameliorated nearly to control values after administration of Gaultheria fragrantissima leaf extract to arthritic animals.
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