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Articles by T.R. Cibin
Total Records ( 2 ) for T.R. Cibin
  T.R. Cibin , G. Srinivas , D. Gayathri Devi , Priya Srinivas , Y. Lija and Annie Abraham
  In this study we have looked into a fairly less studied, common edible plant- Emilia sonchifolia Linn (ES), for possible antioxidant and antitumor activity. We have isolated the flavonoid fraction from the whole plant and the antioxidant property was assessed by measuring its capacity to inhibit Cu2+ induced lipoprotein oxidation in human serum and superoxide production in vitro in comparison with Quercetin. The lag time for ES fraction was 60 minutes, whereas for Quercetin it was 72 min. The inhibitory concentration 50% (IC50) values obtained for superoxide production was 48 μg (Flavonoid fraction of ES) compared to 32 μg for Quercetin. Based on these results, the efficiency of the plant product to inhibit the proliferation of human cancer cells were evaluated. Treatment of the cancer cells with the flavonoid fraction of ES showed morphological changes characteristics of apoptosis, confirmed by Ethidium bromide-Acridine Orange staining.
  D. Gayathri Devi , Y. Lija , T.R. Cibin , P.G. Biju , V. Gayathri Devi and Annie Abraham
  Emilia sonchifolia Linn. (DC.) is a traditionally used medicinal plant seen in most tropical and subtropical regions worldwide. Various parts of the plant are used for the treatment of diseases like asthma, intermittent fevers, breast cancer, ophthalmia, nyctalopia etc. We have isolated the flavonoid fraction from E. sonchifolia (whole plant). Female albino rats were fed with 0.2% sodium perchlorate to induce oxidative stress. The flavonoid fraction of the plant was fed along with sodium perchlorate to another group of animals. The experiment consisted of 30 days. The antiperoxidative effect of the plant material was studied in vivo. The levels of lipid peroxidation products (Thiobarbituric acid reacting substances-TBARS), the activities of the antioxidant enzymes-superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), Glutathione Reductase (GR) and glutathione-S-transferase (GST) as well as the concentration of reduced glutathione (GSH) were determined. The results obtained show that the flavonoid fraction of E. sonchifolia is a potent inhibitor of peroxidative damage and can be used as a therapeutic agent.
 
 
 
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