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Articles by T.P. Prohp
Total Records ( 2 ) for T.P. Prohp
  T.P. Prohp , E.S. Osifo , A.O. Madusha , J.O. Erebor , H.O. Okpala and C.A. Oyinbo
  Study was conducted on the effects of aqueous extract of extra-cotyledonous deposit of Pride of Barbados (Caesalpina pulcherrima) on some blood electrolytes and urea levels in rabbits. Rabbits used were of New Zealand strain and weighed between 1750 and 1900g. About 200ml of the aqueous extract were administered daily to the test rabbits orally through clean drinking troughs for a period of 28 days. Blood was obtained from rabbits intravenously through the larger veins at the back of the ear. Results obtained, showed that the values of Na+, K+, Cl-, HC03-, Mg2+, Ca2+, Phosphorus and urea for control and test ranged from 133-140 and 134-141 mmol/l; 3.8-4.5 and 3.7-5.0 mmol/l; 101-107 and 99-107 mmol/l; 21-27 and 22-28 mmol/l; 4.0-5.2 and 4.9-5.2 mmol/l; 6.5-7.0 and 6.2-7.2 mmol/l; 4.9-6.0 and 5.1-6.1 mg/100ml; 27-35 and 27-34 mg/dl respectively. The above values are within the normal ranges. The aqueous extract of extra-cotyledonous deposit of Pride of Barbados (Caesalpina pulcherrima) may therefore contain agents capable of stabilizing normal electrolyte balance in the blood.
  T.P. Prohp , I.O. Onoagbe , P.C. Onyebuagu , A.A. Omeni , R.I. Okoli and N.P. Obeto
  The effect of aqueous extract of Triplochiton scleroxylon on the body weight, plasma glucose concentration and some hematological parameters in alloxan-induced diabetic rabbits were investigated. Rabbits of the same strain (New Zealand) weighing between 1.20 and 1.68kg were used. At least 100ml of the aqueous extract of the plant was administered to a set of test rabbits for a period of 28 days. Blood was collected for analyses intravenously from the larger vein at the back of the ear of the rabbits. Plasma glucose was analyzed by spectrophotometeric method. Hematological swelab auto - counter 920E+ (UK) was used for red blood cell counts, packed cell volume, hemoglobin and mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin, mean corpuscular volume and red cell distribution width. The aqueous extract of Triplochiton scleroxylon does not have any significant effect (P>0.05) on the body weight and some hematological parameters investigated. However, plasma glucose concentration decreased significantly (P < 0.05) on the 18th, 24th and 28th days of administration of herbal extract to alloxan - induced diabetic rabbits. The crude extract of this herb has an hypoglycemic properties and its use as an anti-diabetic agent may not interfere with the body weight and some hematological properties of rabbits and by extrapolation humans.
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