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Articles by T.O. Oyesola
Total Records ( 4 ) for T.O. Oyesola
  K.O. Ajeigbe , E.O. Nwobodo , T.O. Oyesola , D.A. Ofusori and S.B. Olaleye
  The aim of this study was to investigate the effect of Chloroquine phosphate (at therapeutic dose) on existing gastric ulceration in albino rats. Rats were treated with Chloroquine phosphate (8.5 mg kg-1) intramuscularly for 24 h after formation of ulcers induced by acidified ethanol and indomethacin. Following sacrifice, colorimetric assays were applied to determine the concentration of protein and mucus, activities of catalase and lipid peroxidation in homogenized gastric mucosal samples. Chloroquine phosphate worsens gastric lesions produced by both indomethacin and acidified ethanol. Also, it seemed to elaborate the indomethacin and acidified ethanol induced effects on gastric juice volume, pH and acid output. On the other hand, thiobarbituric acid reactants (TBAR) was further increased and protein, catalase and mucus were decreased in the gastric mucosal samples. The data indicates that the use of Chloroquine may be dangerous to the integrity of the stomach, especially in existing gastric ulcers. It increases oxidative stress in the gastric mucosa caused by indomethacin and acidified ethanol.
  O.A. Oyesola , T.O. Oyesola and A.I. Izagbo
  Fruits have been part of the human diet and supplements. Present study was conducted to investigate pineapple juice (PJ) effects on Gastric Ulcer (GU), since dietary substances or supplements may predispose someone to GU. Thirty-six male wistar rats, weighing 180-200 g were used. They were divided into six groups A-F. Groups A served as control. Group B was not given PJ. Groups C-F received 0.5, 1.0, 1.5 and 2 mL of PJ, respectively. After 30 days, GU was induced with indomethacin. Ulcers Indices (UI) were scored, Total Protein Content (TPC), Catalase (CAT), Superoxide Dismutase (SOD) activities and Lipid Peroxidation (LPP) were determined from stomachs’ tissue. Significances were taken at p<0.05. UI showed significant increases when groups B-F were compared with control. A significant reduction was seen in TPC when groups B-F were compared with control. Comparison of CAT activities between control and groups B-F showed significant reduction in groups B-F and a significant increase in SOD in groups B-F. Activities of anti-oxidant enzymes in group B were compared with groups C-F. Observation showed that CAT activity increased significantly in groups C and D and SOD activity reduced significantly in groups D-F. Observation from LPP in the gastric mucosa showed increase which was significant in group B, when control was compared with groups B-F. When group B was compared with groups C-F, significant increases were observed in groups C and D. Conclusion from results suggested that PJ consumption may predispose, consumer to gastric ulceration because of its tendency to reduce TPC, increase UI and anti-oxidant enzymes.
  T.O. Oyesola , O.A. Oyesola and C.S. Okoye
  Effects of Aspilia africana leaf extract on oestrous cycle and ovulation were studied in adult female Wistar strain rats. Cyclic female rats weighing 150 to 200 g were divided into two study groups: the oestrous study and ovulation study group. For the oestrous study, the experimental group received 500 mg kg-1 b. wt. of the extract for 14 days while the control group received distilled water for the same period. In both groups, vaginal lavage was taken daily from the 5th day to monitor the oestrous cycle. For the ovulation study, there was a control group and two experimental groups. The control group received distilled water while group 1 and 2 received 500 and 1000 mg kg-1 b.wt. of Aspilia africana leaf extract for 16 days, respectively. The animals were sacrificed on the estrous following the treatment. The results showed a significant decrease in the body weight of the treated rats (p = 0.01) and the oestrous cycle was altered after the commencement of extract. This was indicated by the prolonged proestrous and a reduced dioestrus and estrus. There was a dose-dependent reduction in the ovulation s shown by the reduced number of ova observed in the oviduct from the treated rats compared with control (p<0.05). The extract caused inflammation of the fallopian tube, degeneration in the ovarian cortex in the stroma cells of the ovary and disruption of the endometrium of the uterus. Results suggest that aqueous extract of Aspilia africana leaf has antifertility effect by altering oestrous cycle and causing a dose dependent adverse effect on ovulation in Wistar strain rats.
  T.O. Oyesola , F.S. Oluwole and O.A. Oyesola
  The seeds of Croton penduliflorus (Family Euphorbiaccea) are often used as a purgative. The physiological effects of the methanolic extract on some intestinal disaccharide splitting enzymes were investigated in pregnant rats using an in vivo study. The extract was administered orally at a dose of 550 mg kg-1 body weight during the three phases of pregnancy. The extract caused a significant increase in maltase activity in the three phases of pregnancy, a significant increase in total protein concentration in early and late pregnancy and a significant increase in albumin concentration in early and mid pregnancy (p<0.01). The extract also caused a significant increase in sucrase activity in early pregnancy and in lactase activity in mid pregnancy. The present data suggest that increase activity of disaccharidase brush border enzymes most especially sucrase show that the extract might be having hyperplastic (growth) effect on the small intestinal enzyme activities, there is possibility of increased nutrients to the pregnant rats and fetuses.
 
 
 
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