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Articles by T.C. Iwuanyanwu
Total Records ( 1 ) for T.C. Iwuanyanwu
  G.C. Akuodor , C.C. Mbah , A.D. Essien , J.L. Akpan , B.C. Ezeokpo , T.C. Iwuanyanwu and U.A. Osunkwo
  Bridelia ferruginea which have some ethnomedicinal applications was investigated for ulcer-protective and anti-diarrhoeal effects. The ulcer-protective and anti-diarrhoeal activities of the aqueous stem bark extract were examined in rats and mice. Acute toxicity studies were also carried out. The extract exhibited ulcer-protective properties against ethanol and indomethacin induced ulceration activity in rats with maximal anti-ulcer activity observed at 400 mg kg-1. The extract dose dependently decreased intestinal propulsion of charcoal meal in mice. The aqueous extract of Bridelia ferruginea also exerted significant anti-enteropooling in mice. A significant antidiarrhoeal activity was also recorded in mice. The frequency of defaecation as well as the wetness of faecal droppings was reduced. In addition, the extract produced 100% inhibition of castor oil-induced diarrhoea in mice. The oral LD50 obtained was greater than 5000 mg kg-1 in mice. The results show that Bridelia ferruginea stem bark probably contains some active ingredients that potentially could be developed as useful drug for the treatment of ulcer and diarrhoea in Nigerian herbal traditional medicine.
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