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Articles by T. Ono
Total Records ( 3 ) for T. Ono
  M. Fukui , M. Tanaka , M. Yamazaki , G. Hasegawa , M. Nishimura , N. Iwamoto , T. Ono , S. Imai and N. Nakamura
  Aims: Previous studies have implicated reduced serum bilirubin concentrations in the development of cardiovascular disease. The aim of this study was to examine whether bilirubin may explain the high incidence of vascular complications in haemodialysis patients with Type 2 diabetes. Methods: We compared serum bilirubin concentrations, as well as other known aetiological risk factors for cardiovascular disease, in 206 Type 2 diabetes patients on haemodialysis with those in 741 Type 2 diabetes patients not receiving haemodialysis, and evaluated the association between serum bilirubin concentration and cardiovascular disease incidence. Results: Incidences of cardiovascular disease and systolic blood pressure were higher; however, BMI and serum total cholesterol were lower in haemodialysis patients compared with those in patients without haemodialysis. Serum total (0.30 ± 0.10 vs. 0.74 ± 0.26 mg/dl, 0.005 ± 0.002 vs. 0.013 ± 0.004 mmol/l, P < 0.0001) and indirect (0.17 ± 0.08 vs. 0.70 ± 0.23 mg/dl, 0.003 ± 0.001 vs. 0.012 ± 0.004 mmol/l, P < 0.0001) bilirubin were lower in haemodialysis patients compared with those in patients without haemodialysis. Stepwise regression analysis demonstrated that age (β = 0.109, F = 5.959, P < 0.05), duration of diabetes (β = −0.112, F = 6.048, P < 0.05), sex (β = −0.123, F = 8.623, P < 0.05), cardiovascular disease events (β = −0.099, F = 5.131, P < 0.05) and presence of haemodialysis (β = −0.626, F = 201.727, P < 0.01) were independent factors for serum total bilirubin. Logistic regression demonstrated that age (OR 1.089, 95% CI 1.044-1.136; P < 0.0001), duration of diabetes (OR 1.029, 95% CI 1.001-1.059; P = 0.0423), body mass index (OR 1.115, 95% CI 1.001-1.242; P = 0.0487), habit of smoking (OR 2.445, 95% CI 1.046-5.716; P = 0.0391) and serum total bilirubin (OR 0.192, 95% CI 0.037-0.989; P = 0.0484) were independent factors for cardiovascular disease events. Conclusions: Low serum bilirubin concentration could be one of the important factors for the high incidence of cardiovascular disease in Type 2 diabetes patients receiving haemodialysis.
  M. Moniruzzaman , T. Ono , M. Azmi Bustam , S. Yusup and Y. Uemura
  Cellulosic polymers have been extensively used as a potential alternative to organic synthetic polymer in oilfields applications due to many unique and attractive properties, including biodegradable, inexpensive, easy to deal with after use and so on. Among many types of celluloses, wood cellulose has gained increased worldwide interest due to growing global environmental awareness and concepts of sustainability and no conflict between food and chemical/materials production. However, extraction of cellulose from wood biomass with "green" methods is important and challenging for the production of cellulose for further chemical processing. This study describe a new approach for the separation of cellulose from wood biomass with a clean efficient method which combined Ionic Liquids (ILs) pretreatment/recovered steps followed by enzymatic delignification. The pretreatment of wood biomass with the hydrophilic IL (emim) (OAc) (1-ethyl-3-methylimidazolium acetate) was conducted at a range of temperatures (50-80°C). The IL was recovered by washing with water-acetone mixture prior to enzymatic delignification in aqueous systems without or with small amount of ILs. Characterizations of untreated and treated wood materials were performed using SEM, XRD, FTIR, TGA and chemical methods. IL pretreatment did alter the structure to render a more accessible surface area for enzyme. Obtained cellulose fibers became more separated into individual microsized fibers, making it suitable for oil field application. We confidently believe that this newly developed process will play a great role in converting lignocellulosic biomass-the most abundant renewable biomaterials in the world-to biomaterials, biopolymers, biofuels, fracture fluids and natural oil sorbents.
  H Ikehata , R Okuyama , E Ogawa , S Nakamura , A Usami , T Mori , K Tanaka , S Aiba and T. Ono

p53 suppresses the genomic instability provoked by genotoxic agents. Ultraviolet (UV) B induces skin cancers by producing DNA damage and mutations in the skin genome, whereas the skin tissue responds to the UVB insult with cell cycle arrest and apoptosis as well as damage exclusion by DNA repair. To address the p53 contribution to these skin responses in vivo, we analyzed the time course of DNA damage removal, apoptosis induction and hyperplasia in the skin after UVB irradiation in p53-knockout mice. We also examined UVB-induced mutations in the skin. We found that p53 deficiency does not abolish the UVB-induced apoptotic response in the epidermis but delays the process and the following hyperplasia 12–24 h. Regardless of the p53 genotype, 1 kJ/m2 UVB induced a total replacement of the epidermal layer by destroying the damaged epidermis by apoptosis and rebuilding a new one through hyperplasia. We failed to detect a clear defect in removal of UVB-induced DNA photolesions from the genome of the p53-deficient skin except for a delay in the epidermis, which seemed to result from the delay in the apoptotic response. However, we found that p53 deficiency enhanced UVB-induced mutagenesis. Furthermore, in a genetic study using Xpa-knockout mice, we showed that the enhanced mutagenic response depends on the activity of nucleotide excision repair (NER), which was also supported by the mutation spectrum observed in the UVB-exposed p53-knockout mice. These results indicate that p53 protects the skin genome from the UVB genotoxicity by facilitating NER, whereas its contribution to the UVB-induced apoptosis is limited.

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