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Articles by T. Nakamura
Total Records ( 3 ) for T. Nakamura
  T. Nakamura

In this paper, we show relations between the zero-free region and the universality for the Euler–Zagier–Hurwitz type of multiple zeta-functions. Roughly speaking these relations imply that we can obtain the universality for the Euler–Zagier–Hurwitz type of multiple zeta-functions by their zero-free property, and vice versa. Moreover, we obtain the non-trivial zeros, joint denseness and functional independence for the Euler–Zagier–Hurwitz type of multiple zeta-functions.

  M. Kato , M. Noda , H. Suga , T. Nakamura , M. Matsumoto and Y. Kanazawa
  Aims  Using the HbA1c level to define diabetes has several advantages and these advantages also apply to define a high-risk group. However, the risk of diabetes increases as HbA1c increases and a certain degree of arbitrariness in the cut-off for the high risk group is unavoidable. The aim of this study was to determine the HbA1c cut-off for defining a high-risk group that corresponds to the fasting plasma glucose cut-off by comparing the risk of diabetes against the fasting plasma glucose and HbA1c levels in the Japanese population.

Methods  A retrospective cohort study was conducted using data from annual health examinations performed in Omiya city. A total of 11 271 subjects between the ages of 40 and 79 years without diabetes at baseline were followed for up to 7 years. According to the new diagnostic criteria, diabetes was defined as an fasting plasma glucose level ≥ 7 mmol/l or an HbA1c level ≥ 48 mmol/mol (≥ 6.5%) or a self-report. The HbA1c cut-off corresponding to the fasting plasma glucose cut-off was determined using the incidence, hazard ratio, and a receiver operating characteristic analysis.

Results  Eight hundred and sixty subjects developed diabetes. The incidence, hazard ratio, and receiver operating characteristic analysis all indicated that an HbA1c cut-off of 39 mmol/mol (5.7%) corresponded to an fasting plasma glucose level of 5.6 mmol/l.

Conclusions  Our results suggested that the HbA1c cut-off for high-risk of diabetes should be 39 mmol/mol (5.7%), consistent with the American Diabetes Association recommendation. Further research is needed to determine whether our results are applicable to other populations.

  Y. Ono , Y. Ito , K. Kaneko , Y. Shibata-Watanabe , T. Tainaka , W. Sumida , T. Nakamura , H. Kamei , T. Kiuchi , H. Ando and H. Kimura
  Cytomegalovirus (CMV), Epstein-Barr virus (EBV), and human herpesvirus-6 (HHV-6) cause symptomatic diseases in liver transplant recipients. The loads of these viruses, the associations between viral DNAemia, serologic status, and acute rejection reactions were investigated in a group of 17 juvenile and 17 adult recipients of living donor liver transplantation (LDLT) for a median of 8 weeks posttransplantation. At least 1 plasma sample from 15/34 (44.1%) patients was positive for CMV DNA. For most of the CMV-positive patients, the CMV DNA appeared in the second week of LDLT, and disappeared by the eighth week. A minimum of 200 EBV DNA copies/μg peripheral blood mononuclear cell DNA (defined as positive for EBV) was detected in 5/34 (14.7%) patients, and the number of EBV-positive children was significantly greater than the number of EBV-positive adults. In most of the EBV-positive patients, the EBV loads increased after 4 weeks posttransplantation. Plasma HHV-6 was detected in 7/34 (20.6%) patients. HHV-6 DNA appeared for a short period from the second week of LDLT. In addition, 8 of the 19 virus-positive recipients carried 2 viruses, with the combination of CMV and HHV-6 being the most frequent. Serologic status seemed to be an important factor for all 3 viral infections. The rate of acute cellular rejection was not significantly higher in the CMV-, EBV-, or HHV-6-positive groups. Simultaneous monitoring for 3 herpesviruses revealed the impact of these viruses on LDLT recipients.
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