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Articles by T. Matsumoto
Total Records ( 4 ) for T. Matsumoto
  Y Ikeda , K. i Aihara , S Yoshida , T Sato , S Yagi , T Iwase , Y Sumitomo , T Ise , K Ishikawa , H Azuma , M Akaike , S Kato and T. Matsumoto
 

Age-related andropause promotes cardiovascular disease in males. Although we had previously reported that the androgen-androgen receptor (AR) system plays important roles in cardiac growth and remodeling, the system’s involvement in vascular remodeling remains unclear. To clarify this role, 25-wk-old male AR knockout (ARKO) mice and littermate male wild-type (WT) mice were divided into two groups with and without angiotensin II (Ang II) administration (2.0 mg/kg · d) for 14 d, respectively. No morphological differences in the coronary artery and thoracic aorta were observed between the groups without Ang II. Ang II stimulation markedly increased medial thickness and perivascular fibrosis in ARKO mice, with enhanced TGF-β1, collagen type I, and collagen type III gene expression in the aorta. Ang II stimulation also prominently increased superoxide production, lipid peroxidation, and gene expression of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase components in ARKO mice compared with WT mice. In addition, phosphorylation of c-Jun N-terminal kinase (JNK) and phosphorylated (Smad2/3) was remarkably enhanced in Ang II-treated ARKO mice compared with Ang II-treated WT mice. Notably, daily urinary nitric oxide (NO) metabolites excretion as a marker of NO bioavailability, aortic endothelial NO synthase expression and phosphorylation, and Akt phosphorylation were significantly reduced in ARKO mice compared with WT mice, regardless of Ang II stimulation. In conclusion, the androgen-AR system is required for the preservation of NO bioavailability through Akt-endothelial NO synthase system activation and exerts protective effects against Ang II-induced vascular remodeling by regulating oxidative stress, c-Jun N-terminal kinase (JNK) signaling, and the TGF-β-phosphorylated Smad pathway.

  Subejo and T. Matsumoto
  The study has been focused on the transformation process and the influencing factors of the changing of labor exchange arrangements which have been practiced among agrarian communities in rural Java. Practices of labor exchanges in rural Java have been experiencing the transformation process. In lowland areas, the expansion of off-farm jobs and technological changes in rice cultivation has deteriorated labor exchanges; labor exchanges have been almost totally replaced by hired labor. Meanwhile, in the uplands, with limited job opportunities and the introduction of mixed cropping, which demands collective work, labor exchange practices for various farming operations have strengthened considerably. Under geographical limitations and technological changes of mixed cropping system in upland areas, those have stimulated villagers to intensify traditional collective work arrangements such as sambatan and krubutan, which to some extent has been supplemented by the newly invented institution prayaan for completing farming and non-farming activities. The basic structures of the social relationships among villagers both in the upland and lowland hamlets bring about fewer difficulties in the arrangement of collective work for non-farming activities. However, villagers’ division of labor and diversification of income sources may enable well-off households to build modern houses, a process that will likely reduce the need for collective work in the future due to its need for highly skilled labor. Altruistic behavior in house construction is still very common among villagers in the uplands; in contrast, it has gradually disappeared among richer households in the lowland area.
  S. Sendari , H.W. Herwanto , Y. Rahmawati , M. Rizkya , W. Waras , T. Matsumoto and I. Rahman
  This study aims to introduce a building control system which is able to handle a huge number of electrical equipments. The proposed method is named grouping building control systems and was implemented to classroom. The unique point is that a school has a huge number of classrooms which could be grouped in separated buildings. In order to deal with this situations, the idea of grouping controllers might be able to reduce wiring complexity and conform the number of port connections in hardware controlling system. When the system is implemented to classrooms it would be used by a lot of users. Furthermore, maintenance of a huge number of devices should be done regularly. The unique point of the proposed system is that in order to maintain the system a report application could reduce the complexity of maintenance the devices. Considering functionality, the results showed that the system worked as the necessity.
  Y Ikeda , K. i Aihara , M Akaike , T Sato , K Ishikawa , T Ise , S Yagi , T Iwase , Y Ueda , S Yoshida , H Azuma , K Walsh , T Tamaki , S Kato and T. Matsumoto
 

Doxorubicin (Dox) has been used as a potent anticancer agent, but serious cardiotoxicity precludes its use in a wide range of patients. We have reported that the androgen-androgen receptor (AR) system plays important roles in cardiac growth and protection from angiotensin II-induced cardiac remodeling. The present study was undertaken to clarify whether the androgen-AR system exerts a cardioprotective effect against Dox-induced cardiotoxicity. Male AR knockout (ARKO) and age-matched littermate male wild-type (WT) mice at 25 wk of age were given ip injections of Dox (20 mg/kg) or a vehicle. The survival rate and left ventricular function in Dox-treated male ARKO mice were reduced compared with those in Dox-treated male WT mice. Electron microscopic study showed prominent vacuole formation of myocardial mitochondria in Dox-treated male ARKO mice. Cardiac oxidative stress and apoptosis of cardiomyocytes were increased more prominently by Dox treatment in male ARKO mice than in male WT mice. In addition, Dox-induced reduction in the expression of cardiac mitochondria transcription factor A (Tfam) and phosphorylation of serine-threonine kinase (Akt) was more pronounced in male ARKO mice than in male WT mice. In cardiac myoblast cells, testosterone up-regulated Akt phosphorylation and Tfam expression and exerted an antiapoptotic effect against Dox-induced cardiotoxicity. Collectively, the results demonstrate that Dox-induced cardiotoxicity is aggravated in male ARKO mice via exacerbation of mitochondrial damage and superoxide generation, leading to enhanced apoptosis of cardiomyocytes. Thus, the androgen-AR system is thought to counteract Dox-induced cardiotoxicity partly through activation of the Akt pathway and up-regulation of Tfam to protect cardiomyocytes from mitochondrial damage and apoptosis.

 
 
 
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