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Articles by T. Kurita
Total Records ( 2 ) for T. Kurita
  H. Higashino , M. Tabuchi , S. Yamagata , T. Kurita , H. Miya , H. Mukai and Y. Miya
  Since Nitric Oxide (NO) is produced by three types of Nitric Oxide Synthases (NOSs), rapid changes in stable oxidized metabolites (nitrite and nitrate, NOx) in the tissues and blood should be represented by the amount of stable forms in serum and may reflect vascular activities and circulatory or inflammatory changes in the body. Therefore, serum NOx levels in patients with various diseases were measured and compared to healthy controls. Four hundred and sixty five in- and outpatients aged 14 to 96 years were included in this study and 49 healthy hospital workers were included in the control group. The NOx levels of both groups were measured at rest in the morning using an ozone chemiluminescence method. When compared with the control group, serum NOx levels were higher in patients consist of around 40 or more in numbers diagnosed with cardiovascular diseases including myocardial infarction, hyperlipaemia, gastrointestinal diseases including acute enteritis, chronic liver diseases including viral B and C type hepatitis and liver cirrhosis, diabetes in males, hypertension with comorbid diseases. In addition, patient groups with renal disorders, hyperuricemia, osteoporosis, untreated cancers, autoimmune diseases such as Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE) were also higher, although the each number might be not enough to compare between the groups. Patient groups with acute and chronic inflammation had significantly higher serum NOx levels. Therefore, measurement of serum NOx in patients may be useful for understanding the status and pathophysiology of inflammatory diseases and those in which inflammation is a component.
  T. Kurita , K. Nakamura , M. Tabuchi , M. Orita , K. Ooshima and H. Higashino
  The details of pharmacological mechanisms of Gorei-san, a traditional Japanese Kampo medicine, remains to be clarified, although it has been used for diuretic and hydrostatic purposes. From these circumstances, the effects of this medicine on the expressions of aquaporin (AQP) 1, 2, 3, 4 and vasopressin 2 receptor (V2R) mRNAs were investigated in relation to diuresis and water balance regulation in the kidney and brain. Gorei-san extract decocted with hot water was given to rats loaded with 50 mL kg-1 volume of physiological saline and AQP1, 2, 3, 4 and V2R mRNAs were measured with real-time polymerase chain reaction (PCR) in the cortex and the medulla of kidney and the forebrain. A low dose of Gorei-san extract (100 mg kg-1) led to an increase in urine excretion and lower AQP3 mRNA expression in the cortex as well as lower expression of AQP2 and AQP3 mRNAs in the medulla of kidney, whereas no change in V2R mRNA expression was observed. AQP1 mRNA expression decreased in the forebrain of rats loaded with an excess volume of physiological saline compared with rats not loaded with excess saline and given no agent. A low dose of Gorei-san extract increased urine excretion volume, probably due to the downregulation of AQP3 mRNA in the cortex and downregulation of AQP2 and AQP3 mRNAs in the medulla of the kidney, in which changes were not related to V2R mRNA expression. An excess volume of physiological saline given to rats caused an inhibition of AQP1 mRNA expression in the forebrain, which probably functioned to maintain the water balance in a hyper-hydrous state.
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