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Articles by T. Kondo
Total Records ( 2 ) for T. Kondo
  T. Hobiger , M. Sekido , Y. Koyama and T. Kondo
  Next-generation Very Long Baseline Interferometry (VLBI) system designs are aiming at 1 mm global position accuracy. In order to achieve this, it is not only necessary to deploy improved VLBI systems, but also to develop analysis strategies that take full advantage of the observations taken. Since the new systems are expected to incorporate four independent radio frequency bands, it should be feasible to resolve phase ambiguities directly from post-correlation data, providing roughly an order of magnitude improvement in precision of the delay observable. As the unknown ambiguities are of integer nature, it is discussed here how they the can be resolved analytically using algorithms which have been developed for Global Navigation Satellite System (GNSS) applications. Furthermore, it will be shown that ionosphere contribution and source structure effects, so-called core-shifts, can be solved simultaneously with the delay, which is the main geodetic observable for follow-on analysis. In order to verify the proposed algorithm, simulated observations were created using parameters from actual design studies. It is shown that, even in the case of low signal-to-noise ratio observations, reliable phase ambiguity resolution can be achieved and it is discussed how the integer ambiguity recovery depends on the number of observations and signal-to-noise ratio.
  K Kikuta , M Gotoh , T Kanda , N Tochigi , T Shimoda , T Hasegawa , H Katai , Y Shimada , Y Suehara , A Kawai , S Hirohashi and T. Kondo

The clinical course of gastrointestinal stromal tumor (GIST) spans a wide spectrum from a curable disorder to a highly malignant disease that leads to metastasis and death. To develop prognostic modalities for GIST patients, we developed a mouse monoclonal antibody against pfetin, the prognostic value of which has been previously reported.


The reactivity of the monoclonal antibody against pfetin was examined by western blotting and immunohistochemistry.


Western blotting demonstrated that the monoclonal antibody was specific to pfetin. The immunohistochemical study demonstrated that the 5-year disease-free survival rate was 93.2% and 94.5% for GIST patients with pfetin-positive tumors and 70.0% and 80.7% for those with pfetin-negative tumors in the 159 cases from the National Cancer Center Hospital (P < 0.0001) and in the 100 cases from Niigata University Medical and Dental Hospital (P < 0.0001), respectively. Uni- and multivariate analyses revealed that pfetin expression was a powerful prognostic factor among the clinico-pathological parameters examined.


These results establish pfetin as a practical prognostic marker for GIST patients after surgery. Pfetin may also present a novel therapeutic target to prevent recurrence of GIST.

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