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by
T. Sivakumar |
Total Records (
2 ) for
T. Sivakumar |
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R. Sambath Kumar
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T. Sivakumar
,
P. Sivakumar
,
R. Nethaji
,
M. Vijayabasker
,
P.Perumal
,
Malaya Gupta
and
Upal Kanti Mazumder
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The present study was carried out to evaluate the hepatoprotective and antioxidant effect of the Methanol Extract of Careya arborea Roxb (MECA) (Family- Myrtaceae) stem bark in Wistar albino rats. The different groups of animals were administered with carbon tetrachloride (CCl4) (30 % CCl4, 1 mL Kg 1 b. wt. in liquid paraffin 3 doses (i.p.) at 72 h interval). The MECA at the doses of 50, 100 and 200 mg Kg 1 and silymarin 25 mg Kg 1were administered to the CCl4 treated rats. The effect of MECA and silymarin on serum transaminase (GOT, GPT), Alkaline Phosphates (ALP), bilirubin, uric acid and total protein were measured in the rats induced hepatotoxicity by CCl4. Further, the effects of the extract on Lipid Peroxidation (LPO), enzymatic antioxidant (Superoxide Dismutase (SOD) and Catalase (CAT)), and nonenzymatic antioxidant (Glutathione (GSH), vitamin C and vitamin E) were estimated. The MECA and silymarin produced significant (p < 0.05) hepatoprotective effect by decreasing the activity of serum enzymes, bilirubin, uric acid, and lipid peroxidation and significantly (p < 0.05) increased the levels of SOD, CAT, GSH, vitamin C, vitamin E and protein in a dose dependent manner. From these results, it was suggested that MECA possess potent hepatoprotective and antioxidant properties. |
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P. Sivakumar
,
R. Sambath Kumar
,
T. Sivakumar
,
R. Nethaji
,
M. Vijayabaskaran
,
P. Perumal
,
Amit R. Bukkawer
,
B. Jayakar
,
K. Parvathi
and
C. Sarasu
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The purpose of this study was investigating experimentally the possible antitumor effect and antioxidant role of methanol extract of Triumfetta rhomboidea (METR) leaves against Dalton’s ascites lymphoma (DAL) bearing Swiss albino mice. The METR administered at the doses of 100, 200 mg kg 1, in mice for 14 days after 24 h of tumor inoculation. The effects of METR on the growth of murine tumor, life span of DAL bearing mice were studied. Hematological profile and liver biochemical parameters (lipid peroxidation, antioxidant enzymes) were also estimated. Treatment with METR decreased the tumor volume and viable cell count there by increasing the life span of DAL bearing mice. METR brought back the hematological parameter more or less normal level. The effect of METR also decreases the levels of lipid peroxidation and increased the levels of glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT). The present work indicates that the methanol extract of Triumfetta rhomboidea exhibited significant antitumor and antioxidant activity in vivo. |
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