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Articles by T Zimmermann
Total Records ( 2 ) for T Zimmermann
  F Jessen , B Wiese , C Bachmann , S Eifflaender Gorfer , F Haller , H Kolsch , T Luck , E Mosch , H van den Bussche , M Wagner , A Wollny , T Zimmermann , M Pentzek , S. G Riedel Heller , H. P Romberg , S Weyerer , H Kaduszkiewicz , W Maier , H Bickel and Cognition and Dementia in Primary Care Patients Study Group for the German Study on Aging
 

Context  Subjective memory impairment (SMI) is receiving increasing attention as a pre-mild cognitive impairment (MCI) condition in the course of the clinical manifestation of Alzheimer disease (AD).

Objectives  To determine the risk for conversion to any dementia, dementia in AD, or vascular dementia by SMI, graded by the level of SMI-related worry and by the temporal association of SMI and subsequent MCI.

Design  Longitudinal cohort study with follow-up examinations at 11/2 and 3 years after baseline.

Setting  Primary care medical record registry sample.

Participants  A total of 2415 subjects without cognitive impairment 75 years or older in the German Study on Aging, Cognition and Dementia in Primary Care Patients.

Main Outcome Measures  Conversion to any dementia, dementia in AD, or vascular dementia at follow-up 1 or follow-up 2 predicted by SMI with or without worry at baseline and at follow-up 2 predicted by different courses of SMI at baseline and MCI at follow-up 1.

Results  In the first analysis, SMI with worry at baseline was associated with greatest risk for conversion to any dementia (hazard ratio [HR], 3.53; 95% confidence interval [CI], 2.07-6.03) or dementia in AD (6.54; 2.82-15.20) at follow-up 1 or follow-up 2. The sensitivity was 69.0% and the specificity was 74.3% conversion to dementia in AD. In the second analysis, SMI at baseline and MCI at follow-up 1 were associated with greatest risk for conversion to any dementia (odds ratio [OR], 8.92; 95% CI, 3.69-21.60) or dementia in AD (19.33; 5.29-70.81) at follow-up 2. Furthermore, SMI at baseline and amnestic MCI at follow-up 1 increased the risk for conversion to any dementia (OR, 29.24; 95% CI, 8.75-97.78) or dementia in AD (60.28; 12.23-297.10), with a sensitivity of 66.7% and a specificity of 98.3% for conversion to dementia in AD.

Conclusion  The prediction of dementia in AD by SMI with subsequent amnestic MCI supports the model of a consecutive 3-stage clinical manifestation of AD from SMI via MCI to dementia.

  R. B Adusumalli , R Raghavan , P Schwaller , T Zimmermann and J. Michler
 

Fibre deformations such as kinks and micro-compressions are significant parameters in determining the quality of industrial pulps. Undoubtedly, very little information has been obtained so far on fibre deformation because it is very tedious to handle the specimens. In this study, a novel in situ scanning electron microscope (SEM) micro-indentation technique was adopted for the first time to study the deformation of single industrial pulp fibres in the transverse direction. A one-to-one correspondence between load drops in load–displacement curve and cell wall deformation was obtained by using the SEM video sequence recorded during micro-indentation. The cell wall deformation occurred by ‘elastic’ sinking-in and lateral bulging of the microfibrils. Finally, the critical load (stress) required to initiate a crack in the cell wall was measured for different unbleached pulp fibres.

 
 
 
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