VH/VL interface engineering to promote selective expression and inhibit conformational isomerization of thrombopoietin receptor agonist single-chain diabody

T Igawa, H Tsunoda, Y Kikuchi, M Yoshida, M Tanaka, A Koga, Y Sekimori, T Orita, Y Aso, K Hattori and M. Tsuchiya

Protein Engineering, Design and Selection 23 ( 8 ): 667 - 677 , 2010