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Articles by Syed Rafatullah
Total Records ( 3 ) for Syed Rafatullah
  Syed Rafatullah , Abdulmalik Al-Sheikh , Saleh Alqsoumi , Mohammed Al-Yahya , Kamal El-Tahir and Ahmed Galal
  The fresh juice obtained from the locally grown radish root was tested for possible hepatoprotective effect against carbon tetrachloride-induced hepatocellular damage in albino rats. The juice at two doses of 2 and 4 mL/kg/rat for five consecutive days, exhibited a significant dose-dependent protective effect. The magnitude of protection was measured by using biochemical parameters including determination of Serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP), bilirubin (Bil) and non-protein sulfhydryl content in the liver tissues (NP-SH), in addition to histopathological assessment. The protective effect was demonstrated in lowering the elevated serum levels of SGPT, SGOT, Bil, ALP and increasing NP-SH level. Silymarin, a known hepatoprotective agent was used as a positive control. Biochemical data were further supported by the histopathological results. The phytochemical examination of the fresh juice revealed the presence of sulfurated, phenolic and terpenoid compounds in radish.
  Saleh Alqasoumi , Tajdar Husain Khan , Mohammed Al-Yahya , Ibrahim Al-Mofleh and Syed Rafatullah
  Spices viz., Allium cepa (AC), Allium sativum (AS), Anethum graveolens (AG), Capsicum annuum (CA) and Carum carvi (CC) were assessed for their safety. The safety evaluation study included acute toxicity (24 h), chronic toxicity (90 days), LD50 and/or Maximum Tolerance Dose (MTD) and genotoxicity determination. During chronic treatment, the body and organ weights of the mice showed no significant difference between the control and the treated group. The treatment of AC, AS, AG, CA and CC dose not induce any significant change in the frequency of micronucleated-polychromatic erythrocytes (PCE) and the ratio of PCE and non-chromatic erythrocytes (NCE), indicating lack of clastogenic activity except AG and CA which shows a significant increase in the frequency of micronuclei in PCE as compared to the control group (p<0.05). These findings suggest that orally administrated aqueous suspension of above mentioned spices is relatively safe.
  Ibrahim Al-Mofleh , Mohamed Al-Sobaihani , Saleh Alqasoumi , Mansour Al-Said , Mohammed Al-Dosari , Mohamed Al-Yahya and Syed Rafatullah
  This study evaluated anti-gastric ulcer and anti-secretory effects of folkloric medicinal plant, Foeniculum vulgare L., (Family:Apiaceae) in rats. The gastric ulcer protective potential of an aqueous suspension of 'Fennel' Foeniculum vulgare (FVS) was evaluated against different acute gastric ulcer models in rats induced by pyloric ligation (Shay), hypothermic restraint stress, indomethacin and by necrotizing agents (80% ethanol, 0.2 M NaOH and 25% NaCl). Fennel suspension, 250 and 500 mg kg-1 b.wt. administered orally (intraperitoneally in Shay rat model) showed a dose-dependent ulcer protective effects in all the above models. Besides, the FVS offered protection against ethanol-induced depletion of Gastric Wall Mucus (GWM); replenished the reduced nonprotein sulfhydryls (NP-SH) concentration and modulated malondialdehyde (MDA) contents in the gastric tissue. Ethanol induced histopathological lesions of the stomach wall characterized by mucosal hemorrhages and edema that was reversed by FVS. Pretreatment of rats with FVS provided significant protection of gastric mucosa through its antioxidant capacity and/or by attenuating the offensive and by enhancing the defensive factor.
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