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Articles by Swathi Putta
Total Records ( 2 ) for Swathi Putta
  Eswar Kumar Kilari , Swathi Putta , Rohini Koratana , Neelakanta Rao Nagireddy and Absar Ahmad Qureshi
  The involvement of free radicals and oxidative reactions in protein glycoxidation processes, compounds with antioxidant activity have been tested in order to reduce or to stop glycoxidation. In this study, the antioxidant potential of methonolic pericarp extract of Feronia limonia (MPFL) was evaluated using different in vitro assays including the scavenging activities of super oxide radical, hydroxyl radical, hydrogen peroxide, DPPH radical, Nitric oxide radical and Fe+3radical scavenging activity. The extract was evaluated for antioxidant potential by the phosphomolybdenum method, Fe+2 chelating activity, Ferric Reducing Ability Power (FRAP) and 2, 2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid (ABTs) radical scavenging assay. The results indicated that the MPEF possesses the highest antioxidant activity. To establish the link between glycation and oxidation processes, further the extract have been evaluated for its in vitro antiglycation activities like the inhibitory activities on Bovine Serum Albumin (BSA) and protein oxidation markers including Protein Carbonyl Formation (PCO). The MPFL extract at different concentrations (25-100 μg mL-1) has significantly quenched the fluorescence intensity of glycated BSA and the glycoxidation measured in terms of advanced glycation end products (AGEs). Furthermore, the study demonstrate that the inhibitory effects of MPFL extract in preventing oxidative protein damages including effect on PCO formation which are believed to form under the glycoxidation processes. These results clearly demonstrate that the MPFL is capable of suppressing the formation of AGEs and protein oxidation in vitro might be due to the presence of active principles like volatile flavour and free fatty acids.
  Swathi Putta and Eswar Kumar Kilari
  Diabetes mellitus is a chronic metabolic disorder characterized by raise in blood glucose levels known as hyperglycemia. In the present study, the methonolic pericarp extract of Feronia limonia (MPFL) was evaluated for hypoglycemia and its antihyperglycemic activity in streptozotocin-induced diabetic rats. The percentage inhibition of blood glucose levels in hypoglycemic activity of MPFL 150 and 300 mg kg-1 were found to be 26.91±0.53 (3 h) and 34.67±0.93 (6 h) and 22.53±0.32 (3 h) and 25.24±0.78 (6 h) hypoglycaemic normal rats. The antihyperglycemic activity of MPFL with 150 and 300 mg kg-1 in STZ induced diabetic rats were found to be 31.38±0.77 and 35.42±0.71 at 6 h, respectively. The biphasic reduction was observed in both in normal and diabetic rats might be due to biphasic absorption or biliary secretion of the active principle present in MPFL. Further the samples from diabetic rats were estimated for lipid profile. The lipid profile parameters were significantly brought back to near normal by the treatment if MPFL for 12 weeks. At the end of 12 weeks study period the serum parameters like bilirubin, creatinine, total protein, albumin, uric acid and urea were found to be increased in diabetic rats and treatment with MPFL there is a significant reduction in all the parameters. So, the MPFL found to have significant antihyperglycemic, antihyperlipedemia activity and significant protection against the damage to kidney. Which might be due to antioxidant potential present in the MPFL.
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