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Articles by Susi Edrini
Total Records ( 2 ) for Susi Edrini
  Asmah Rahmat , Susi Edrini , Abdah Md. Akim , Patimah Ismail , Taufiq Yap Yun Hin and Mohd Fadzelly Abu Bakar
  The antiproliferative activities of Strobilanthes crispus was evaluated using (3-[4,5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazoliumbromide) (MTT) assay against several cancer cell lines and Chang liver (normal) cell lines. The methanolic extracts of Strobilanthes crispus displayed the strongest cytotoxic effect on colon cancer (Caco-2) followed by human breast cancer hormone non-dependent (MDA-MB-231) and liver cancer (HepG-2) with IC50 values of 22.3, 27.2 and 29.3 μg mL-1, respectively. The chloroform extract of this plant was shown to also have cytotoxic effect against Caco-2 and HepG-2 with IC50 values of 25.1 and 28.0 μg mL-1, respectively. β-sitosterol and stigmasterol were isolated from the leaves of Strobilanthes crispus. β-sitosterol displayed cytotoxic properties against Caco-2, HepG-2 and MCF-7 with IC50 values of 20.0, 53.0 and 71.2 μM, respectively. Whereas, stigmasterol inhibited the proliferation of Caco2, HepG2, MCF-7 and MDA-MB-231 with IC50 values of 132.5, 182.5, 156.0 and 185.9 μM, respectively. There was no cytotoxic effect observed on normal cell lines (Chang liver) in all samples tested.
  Asmah Rahmat , Susi Edrini , Patimah Ismail , Taufiq Yap Yun Hin and Mohd Fadzelly Abu Bakar
  The aimed of this study is to extract the essential oil from Strobilanthes crispus (Acanthaceae) and Lawsonia inermis Linn (Lythraceae) and to investigate the chemical constituents, antioxidant activity and cytotoxicity effects of these oils on several cancer cell lines and normal cell lines. From GC-MS analysis revealed that the presence of at least 28 components for Strobilanthes crispus and 23 components in Lawsonia inermis. The total antioxidant activity from (FTC) and (TBA) methods showed that the essential oils of both plants have higher antioxidant activity compared to α-tocopherol. The essential oil from Lawsonia inermis displayed the strongest cytotoxic effect on liver cancer cell lines (HepG2) with IC50 (concentration that inhibit 50% of cell proliferation) value of 24 μg mL-1. However, the essential oil from Strobilanthes crispus did not give any cytotoxic value against all the cell lines tested. No cytotoxic effects of both oils in normal cell lines. The essential oils from both plants can be used as nutraceutical supplement to increase antioxidant needed in body to enhance defence systems, especially towards the incidence of degenerative diseases. The essential oil from Lawsonia inermis can be used as supplement in cancer patients especially in liver cancer patients.
 
 
 
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